{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:59:07Z","timestamp":1790654347038,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["10002556"],"award-info":[{"award-number":["10002556"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["10004139"],"award-info":[{"award-number":["10004139"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To adapt and validate a linear binning technique, developed for hyper\u2010polarized 129Xe MRI, for functional lung MRI with matrix\u2010pencil decomposition (MP)\u2010MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      First, a dedicated normalization was applied to the perfusion\u2010weighted and the ventilation\u2010weighted map histograms. Then, using 154 MP\u2010MRI scans of healthy children, reference bins were defined around the peak of the averaged histogram as normal (\u00b11 SD), high (&gt;\u20091 SD), low (between \u22121 SD and \u22122 SD), and defect (&lt;\u2009\u22122 SD), and subsequently applied to a validation dataset comprising healthy children (HC,\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200941) and children with cystic fibrosis (CF,\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200930) to evaluate the accuracy of the classification and its discriminatory power. Furthermore, a third dataset comprising children with CF pre and post elexacaftor\/tezacaftor\/ivacaftor (ETI) therapy (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200924) was binned to evaluate the method's sensitivity to treatment effects. Standard outcome parameters, computed with a median threshold, served as a comparison.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The adapted linear binning resulted in significantly higher defect and low percentages for perfusion and ventilation between children with CF and HC (\n                      <jats:italic>p<\/jats:italic>\n                      values &lt;\u20090.0001) with high discrimination (AUCs &gt;\u20090.85). This was comparable to the standard median\u2010threshold method. Two illustrative cases were included to demonstrate the complementary granularity of the linear binning method. Although standard thresholding indicated improvement in both ventilation and perfusion defects pre and post ETI, linear binning showed that perfusion improvement was restricted to the low category.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A linear binning method for MP\u2010MRI was developed and validated, providing a healthy reference based on a large dataset and advancing functional lung image processing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70544","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:33:47Z","timestamp":1786682027000},"page":"2708-2720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adapted Linear Binning Method to Assess Pulmonary Ventilation and Perfusion in Children Using Lung Matrix Pencil Decomposition (\n                    <scp>MP<\/scp>\n                    )\u2010\n                    <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6034-9103","authenticated-orcid":false,"given":"Marion","family":"Curdy","sequence":"first","affiliation":[{"name":"Pediatric Respiratory Medicine, Department of Pediatrics Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4781-3418","authenticated-orcid":false,"given":"Carmen","family":"Streibel","sequence":"additional","affiliation":[{"name":"Pediatric Respiratory Medicine, Department of Pediatrics Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"Graduate School for Health Sciences University of Bern  Bern 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