{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:59:13Z","timestamp":1790654353772,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["535829883"],"award-info":[{"award-number":["535829883"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To enable MRI\u2010based nongated 3D depiction of forced expiration with both high spatio\u2010temporal resolution and fidelity of lung dynamics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An undersampled 3D Fermat looped, orthogonally encoded trajectory (FLORET) was optimized for nonsegmented dynamic acquisitions during forced expiration and a corresponding model\u2010based reconstruction pipeline promoting spatial and temporal total variation was implemented. The approach was first optimized and validated using a lung phantom, specifically constructed for this study and was then translated to in vivo measurements. This allowed high temporal resolution of 200\u2009ms and isotropic spatial resolution of 5\u2009mm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Volumes derived by segmenting the MR images of the phantom demonstrated excellent agreement with the air exchange measured directly at the phantom within the bore, therefore confirming the validity of the approach. In both phantom and in vivo experiments, the dynamic deflation process could be successfully depicted, confirming the potential for assessing forced expiration with 3D UTE FLORET MRI. From the segmented volumes in vivo, quantitative parameters were derived, including the duration of the dynamic phase (2.8\u2009\u00b1\u20090.2\u2009s), the time to 90% deflation (1.8\u2009\u00b1\u20090.2\u2009s), and the volume change within the first second (2.8\u2009\u00b1\u20090.2\u2009L).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The phantom and in vivo studies demonstrate, that the 3D FLORET trajectory can be utilized to study lung deflation during forced expiration with high temporal resolution of 200\u2009ms and isotropic spatial resolution of 5\u2009mm using a TV\u2010regularized primal\u2010dual SENSE reconstruction. Acquisitions were performed for discrete distinct time frames, that is, no segmented k\u2010space filling across several respiratory cycles was used.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70545","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T09:36:29Z","timestamp":1785144989000},"page":"2698-2707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Image\u2010Derived Volumetry During Forced Expiration Using a\n                    <scp>3D<\/scp>\n                    Fermat Looped, Orthogonally Encoded Trajectory"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7156-2647","authenticated-orcid":false,"given":"Sebastian","family":"Scheidel","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital W\u00fcrzburg  W\u00fcrzburg 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Pediatric Radiology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6207-9226","authenticated-orcid":false,"given":"Herbert","family":"K\u00f6stler","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3585-5442","authenticated-orcid":false,"given":"Simon","family":"Veldhoen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin 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