{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:58:34Z","timestamp":1790654314965,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004046","name":"Karen Elise Jensens Fond","doi-asserted-by":"publisher","award":["30\/6\u20102022"],"award-info":[{"award-number":["30\/6\u20102022"]}],"id":[{"id":"10.13039\/501100004046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005747","name":"A.P. M\u00f8ller og Hustru Chastine Mc-Kinney M\u00f8llers Fond til almene Formaal","doi-asserted-by":"publisher","award":["23\/1\u20102021"],"award-info":[{"award-number":["23\/1\u20102021"]}],"id":[{"id":"10.13039\/501100005747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Pulmonary hypertension is related to a 1\u2010year mortality ranging from &lt;\u20095% to &gt;\u200920% in low\u2010 and high\u2010risk groups. Right heart catheterization is the diagnostic gold standard, associated with a 1.1% rate of severe adverse events, posing the need for a non\u2010invasive diagnostic tool. This study aims to delineate the effects of controlled changes on pulmonary hemodynamics by quantifying corresponding changes in hyperpolarized\n                      <jats:sup>129<\/jats:sup>\n                      Xe MRSI dissolved\u2010phase parameters, including RBC oscillations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seven Danish Landrace pigs underwent hyperpolarized\n                      <jats:sup>129<\/jats:sup>\n                      Xe dissolved\u2010phase 3D MRSI with interleaved MRS under baseline conditions and three vasoactive interventions, monitored with invasive catheters or phase\u2010contrast MRI. Results were evaluated using one\u2010way ANOVA or mixed\u2010effects analysis followed by Dunnett's multiple comparisons test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Hypoxia increased mPAP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038), reduced RBC:M (\u221231%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) and RBC:G (\u221234%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009), while increasing RBC chemical shift (0.57%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020). Adenosine and dobutamine increased RBC:M (22%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and RBC:G (30%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009), while decreasing RBC chemical shift (\u22120.38%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.11). Linear regression revealed an inverse correlation between mPAP and RBC oscillation amplitude (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.158,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), RBC:M (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.25,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05), and RBC:G (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.22,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study demonstrates that dissolved\u2010phase hyperpolarized\n                      <jats:sup>129<\/jats:sup>\n                      Xe MRSI parameters are sensitive to hemodynamic changes, exhibiting consistent inverse relationships with invasively measured mPAP. By leveraging concurrent invasive reference measurements, these findings provide physiological validation that dissolved\u2010phase\n                      <jats:sup>129<\/jats:sup>\n                      Xe metrics reflect pulmonary vascular pressure, supporting their further development as a non\u2010invasive adjunct to right heart catheterization.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70546","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T07:30:15Z","timestamp":1786001415000},"page":"2588-2600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlating Pulmonary Hemodynamics With\n                    <scp>\n                      HP\n                      <sup>129<\/sup>\n                      Xe\n                    <\/scp>\n                    Dissolved\u2010Phase\n                    <scp>MRSI<\/scp>\n                    in a Controlled Porcine Intervention Study"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6112-0280","authenticated-orcid":false,"given":"Markus Phillip","family":"Andersen","sequence":"first","affiliation":[{"name":"MR Research Centre, Department of Clinical Medicine Aarhus University  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias Hedegaard","family":"Kristensen","sequence":"additional","affiliation":[{"name":"MR Research Centre, Department of Clinical Medicine Aarhus University  Aarhus N Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine Regional Hospital Viborg  Viborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5512-9870","authenticated-orcid":false,"given":"Esben S\u00f8vs\u00f8 Szocska","family":"Hansen","sequence":"additional","affiliation":[{"name":"MR Research Centre, Department of Clinical Medicine Aarhus University  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf F.","family":"Schulte","sequence":"additional","affiliation":[{"name":"GE HealthCare  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Redda","sequence":"additional","affiliation":[{"name":"MR Research Centre, Department of Clinical Medicine Aarhus University  Aarhus N Denmark"},{"name":"Department of Surgery Regional Hospital Randers  Randers Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9188-2162","authenticated-orcid":false,"given":"Uffe","family":"Kj\u00e6rgaard","sequence":"additional","affiliation":[{"name":"MR Research Centre, Department of Clinical Medicine Aarhus University  Aarhus N Denmark"},{"name":"Department of Surgery Regional Hospital Horsens  Horsens Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7666-6819","authenticated-orcid":false,"given":"Michael","family":"Vaeggemose","sequence":"additional","affiliation":[{"name":"MR Research Centre, Department of Clinical Medicine Aarhus University  Aarhus N Denmark"},{"name":"GE HealthCare  Br\u00f8ndby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0317-2911","authenticated-orcid":false,"given":"Christoffer","family":"Laustsen","sequence":"additional","affiliation":[{"name":"MR Research Centre, Department of Clinical Medicine Aarhus University  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913\u20102018"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00068002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28609"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/tomography7030039"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.10.005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012192"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010200003000\u201000031"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11102172"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxac.2017.03.121"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnmrs.2020.11.002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26225"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1522\u20102594(200004)43:4<491::aid\u2010mrm1>3.0.co;2\u20106"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099\u20101492(200006)13:4<234::aid\u2010nbm632>3.0.co;2\u2010k"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25794"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00186.2020"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27377"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29602"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522\u20102594(200009)44:3<349::aid\u2010mrm2>3.0.co;2\u2010j"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/tomography8050215"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00035\u20102022"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00440.2024"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rli.0000258655.58753.5d"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.001415"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1995.268.5.H1862"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2019.03.010"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0001\u20102998(99)80018\u2010x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421\u2010014\u20102921\u2010y"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)28987-X"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.121.153201"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4029"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185356"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.70063"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2004.02.014"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2010"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c100002"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748\u20101716.2010.02232.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.30586"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00710.2002"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00326.2014"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13265"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.S149727"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.273.3.H1126"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.25259\/jcis_36_2020"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.artres.2014.07.001"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2021.03.014"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7826193"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.70546","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrm.70546","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.70546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:43:49Z","timestamp":1790653429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.70546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1002\/mrm.70546"],"URL":"https:\/\/doi.org\/10.1002\/mrm.70546","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]},"assertion":[{"value":"2026-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}