{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:58:50Z","timestamp":1790654330715,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2021 SGR 00969"],"award-info":[{"award-number":["2021 SGR 00969"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate lesion severity distribution in ischaemic brain lesions in spontaneously hypertensive rats (SHR) subjected to 90\u2010min transient middle cerebral artery occlusion (tMCAO), and to determine whether epigenetically based neuroprotection modifies lesion severity profiles using a voxel\u2010wise T2 distribution framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Theory and Methods<\/jats:title>\n                    <jats:p>Stroke treatments are commonly evaluated by quantifying infarct size using histology or MRI, approaches that average across lesions and may obscure heterogeneous tissue responses. SHR underwent 90\u2010min intraluminal MCAO and received suberoylanilide hydroxamic acid (SAHA) 4\u2009h after reperfusion. Quantitative T2 maps were acquired at Days 1 and 8 postocclusion. Voxel\u2010wise histogram analysis defined severity thresholds (T2\u2009&lt;\u200970\u2009ms mild; 70\u201390\u2009ms moderate; &gt;\u200990\u2009ms severe). Region\u2010stratified RT\u2010qPCR assessing neuronal, inflammatory, and apoptotic markers provided complementary biological context for interpreting region\u2010 and severity\u2010resolved MRI patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Severity\u2010bin stratification of voxel\u2010wise T2 values quantified how lesion composition redistributed from severe toward moderate\/mild classes across time and regions (cortex vs. subcortex) in association with SAHA treatment. Cortical molecular markers corroborated imaging\u2010defined tissue preservation but did not resolve subcortical differences detected by voxel\u2010wise MRI. Untreated animals exhibited partial spontaneous attenuation of extreme subcortical T2 abnormalities. Histogram descriptors correlated with behavioral outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Voxel\u2010wise T2 distribution analysis provides a complementary, severity\u2010stratified description of lesion composition and its evolution over time, alongside conventional endpoints such as infarct volume and mean\/median T2. The approach is readily applicable in preclinical MRI and is potentially translatable, warranting further validation across broader imaging settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70552","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T11:50:33Z","timestamp":1786017033000},"page":"2870-2884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Voxel\u2010Wise\n                    <scp>T2<\/scp>\n                    Distribution Framework for Lesion Severity Stratification and Treatment\u2010Response Assessment in Stroke: Insights Into Suberoylanilide Hydroxamic Acid\u2010Induced Neuroprotection"],"prefix":"10.1002","volume":"96","author":[{"given":"Andrea","family":"D\u00edaz\u2010P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Therapeutic and Toxicology Universitat Aut\u00f2noma de Barcelona  Cerdanyola del Vall\u00e8s Spain"},{"name":"Institut of Neurosciences, Universitat Aut\u00f2noma de Barcelona  Cerdanyola del Vall\u00e8s Spain"},{"name":"Department of Cell Biology, Physiology and Immunology Universitat Aut\u00f2noma de Barcelona  Cerdanyola del Vall\u00e8s Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Penas","sequence":"additional","affiliation":[{"name":"Institut of Neurosciences, Universitat Aut\u00f2noma de Barcelona  Cerdanyola del Vall\u00e8s Spain"},{"name":"Department of Cell Biology, Physiology and Immunology Universitat Aut\u00f2noma de Barcelona  Cerdanyola del Vall\u00e8s Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Jim\u00e9nez\u2010Altay\u00f3","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Therapeutic and Toxicology Universitat Aut\u00f2noma de Barcelona  Cerdanyola del Vall\u00e8s Spain"},{"name":"Institut of Neurosciences, Universitat Aut\u00f2noma de Barcelona  Cerdanyola del Vall\u00e8s Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8127-6425","authenticated-orcid":false,"given":"Silvia","family":"Lope\u2010Piedrafita","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Biophysics Unit Universitat Aut\u00f2noma de Barcelona  Cerdanyola del Vall\u00e8s Spain"},{"name":"Servei de Resson\u00e0ncia Magn\u00e8tica Nuclear, Universitat Aut\u00f2noma de Barcelona  Cerdanyola del Vall\u00e8s Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBERBBN), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156769"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1565379"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31269-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.048015"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.26867"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X18666200114160844"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01398.x"},{"issue":"3","key":"e_1_2_10_9_1","first-page":"S121","article-title":"Translational Medicine for Stroke Drug Discovery: The Pharmaceutical Industry Perspective","volume":"40","author":"Feuerstein G. 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