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A newly developed PDFF quantification method accounting for resonance shifts and dual\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      * rates was applied on standard 6\u2010point CSE acquisitions of Duchenne (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915), Becker (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931), and facioscapulohumeral (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) muscular dystrophy patients, and control subjects (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940). The impact of frequency shifts, decay functions, and lipid models on PDFF estimation was systematically assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Accounting for resonance shifts resulted in large PDFF quantification differences compared to a reference method (\u22123.8% [\u221214.8%, 7.2%]), significantly improved fitting quality (Bayesian Information Criterion (BIC) difference\u2009\u2265\u200910), and reduced fat\/water separation artifacts, confirming predictions by numerical simulations. Bias and variability due to the lipid model were reduced to less than 1%. Fitting quality in high\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      * regions was further improved using a dual relaxation model with linear\/quadratic decay (BIC difference \u2265\u20092). Sensitivity to change was improved on the tested cohorts (SRM increased by 0.18). DTI\u2010estimated angular dependencies reflected theoretical and numerical predictions for elongated axially symmetric lipid deposits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The proposed approach improvements could enhance the PDFF quantification reliability in neuromuscular disorders studies and support more accurate monitoring of myosteatosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70565","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:21:14Z","timestamp":1786681274000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Lipid\u2010Induced Magnetic Microstructure on Fat Fraction Quantification in Muscular Dystrophies"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8955-4648","authenticated-orcid":false,"given":"Pierre\u2010Yves","family":"Baudin","sequence":"first","affiliation":[{"name":"Institute of Myology, Neuromuscular Investigation Center NMR Laboratory  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0777-2711","authenticated-orcid":false,"given":"Harmen","family":"Reyngoudt","sequence":"additional","affiliation":[{"name":"Institute of Myology, Neuromuscular Investigation Center NMR Laboratory  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Schunk","sequence":"additional","affiliation":[{"name":"Institute of Radiology, University Hospital Erlangen Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Graf","sequence":"additional","affiliation":[{"name":"Institute of Radiology, University Hospital Erlangen Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Lena","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital Erlangen Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Starke","sequence":"additional","affiliation":[{"name":"Institute of Radiology, University Hospital Erlangen Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Roemer","sequence":"additional","affiliation":[{"name":"Institute of Radiology, University Hospital Erlangen Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"},{"name":"Department of Radiology, Chobanian &amp; 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