{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:51:35Z","timestamp":1791175895762,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["5R01EB032801"],"award-info":[{"award-number":["5R01EB032801"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To improve free\u2010breathing low\u2010dose quantitative dynamic contrast\u2010enhanced (DCE) MRI for imaging pancreatic ductal adenocarcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We introduced non\u2010rigid (NR) motion compensation (MoCo) into MR Multitasking using a novel \u201cin\u2010subspace\u201d formulation that directly applies motion fields to spatial feature maps (eigenimages), reducing computational cost relative to warping in the spatiotemporal domain. We evaluated NR\u2010MoCo DCE Multitasking in\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911 healthy volunteers scanned using 20% (0.02\u2009mmol\/kg) of the standard Gd dose; 10 of these volunteers underwent a repeat 20%\u2010dose scan after exiting and re\u2010entering the scanner. Data were reconstructed without MoCo (No\u2010MoCo), translation MoCo (Tr\u2010MoCo), and NR\u2010MoCo Multitasking. We assessed motion by measuring respiratory motion energy ratio and liver dome position across time within the end\u2010expiration respiratory bin. We estimated pharmacokinetic parameters from all reconstruction frameworks, evaluating the test\u2013retest repeatability of parameters in the head, body, and tail of the pancreas.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Non\u2010rigid MoCo of eigenimages was compatible with MR Multitasking, using &gt;\u20093000\u00d7 fewer Fourier transforms and motion deformations. Compared with Tr\u2010MoCo and No\u2010MoCo, NR\u2010MoCo showed the best performance in reducing artifactual intra\u2010bin motion along DCE dimension, indicated by the smallest liver\u2010dome position variation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026). NR\u2010MoCo lowered the effective tensor rank and improved repeatability of quantitative kinetic vascular properties across healthy volunteers as compared to No\u2010MoCo. The Bland\u2013Altman analysis indicated that NR\u2010MoCo narrowed\n                      <jats:italic>K<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>trans<\/jats:italic>\n                      <\/jats:sup>\n                      limits of agreement by 2.1\u00d7 relative to No\u2010MoCo and Tr\u2010MoCo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Non\u2010rigid motion compensation reduces respiratory motion and improves\n                      <jats:italic>K<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>trans<\/jats:italic>\n                      <\/jats:sup>\n                      repeatability in low\u2010dose free\u2010breathing, whole\u2010abdomen quantitative dynamic contrast enhanced (DCE) MR Multitasking.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70568","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:12:33Z","timestamp":1791173553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010Rigid Motion\u2010Compensated\n                    <scp>MR<\/scp>\n                    Multitasking for Free\u2010Breathing Low\u2010Dose Dynamic Contrast\u2010Enhanced\n                    <scp>MRI<\/scp>\n                    in the Abdomen"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5620-5597","authenticated-orcid":false,"given":"Lingceng","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Radiological Sciences David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaowei","family":"Wu","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Research Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Wang","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Research Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsu\u2010Lei","family":"Lee","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Research Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8417-2819","authenticated-orcid":false,"given":"Junzhou","family":"Chen","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Research Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-8254","authenticated-orcid":false,"given":"Zheyuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences David Geffen School of Medicine at UCLA  Los Angeles California USA"},{"name":"Department of Bioengineering University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Xie","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Research Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Pandol","sequence":"additional","affiliation":[{"name":"The Karsh Division of Gastroenterology and Hepatology Cedars Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Gaddam","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debiao","family":"Li","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Research Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"},{"name":"Department of Bioengineering University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9334-8684","authenticated-orcid":false,"given":"Anthony G.","family":"Christodoulou","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences David Geffen School of Medicine at UCLA  Los Angeles California USA"},{"name":"Department of Bioengineering University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"issue":"9","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15092584","article-title":"Current Approaches for the Curative\u2010Intent Surgical Treatment of Pancreatic Ductal Adenocarcinoma","volume":"15","author":"S\u0142odkowski M.","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"1","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1148\/radiol.12120111","article-title":"Solid Pancreatic Lesions: Characterization by Using Timing Bolus Dynamic Contrast\u2010Enhanced MR Imaging Assessment\u2014A Preliminary Study","volume":"266","author":"Kim J. 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