{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:07:07Z","timestamp":1789016827797,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012353","name":"Deutschen Konsortium f\u00fcr Translationale Krebsforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012353","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To design and validate a reproducible in vivo\u2010like fat\u2010containing CEST phantom that enables robust quantitative CEST MRI for body applications by providing physiologically realistic relaxation properties, relevant endogenous CEST contrasts (amide, guanidino, rNOE, and semi\u2010solid MT), and a controlled fat component.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An agar\u2010based water\u2010fat CEST phantom was designed using agar, gelatin, and bovine serum albumin, with adjustable fat fraction (FF) achieved through stable water\u2010fat emulsions. Phantom composition was tuned to reproduce tissue\u2010relevant T\n                      <jats:sub>1<\/jats:sub>\n                      and T\n                      <jats:sub>2<\/jats:sub>\n                      relaxation times and physiological pH. The accuracy and temporal stability of FFs and CEST contrasts were assessed over a 3\u2010month period. Low\u2010power CEST MRI at 7T was performed to quantify amide, guanidino, and rNOE contrasts using the inverse metric MTR\n                      <jats:sub>Rex<\/jats:sub>\n                      , and their concentration dependence and temporal stability were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The proposed phantom\u2010generated Z\u2010spectra closely resembled in vivo body CEST measurements and reproduced major endogenous CEST and semi\u2010solid MT effects with controllable contrast levels. Stable and reproducible FF values were achieved for FFs up to 50% over the investigated 3\u2010month period, covering the clinically relevant range for most body tissues. Quantitative CEST metrics demonstrated linear concentration dependence and good temporal stability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An in vivo\u2010like, fat\u2010containing CEST phantom was developed and validated as a reproducible and physiologically relevant reference standard for quantitative body CEST MRI. By enabling controlled investigation of fat\u2010induced effects on CEST contrast quantification, this phantom supports the standardized validation of fat suppression and correction strategies and facilitates methodological development and cross\u2010study comparability in body CEST imaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70585","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:13:01Z","timestamp":1789013581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design of an In Vivo\u2010Like Phantom for Quantitative Body\n                    <scp>CEST MRI<\/scp>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8193-6991","authenticated-orcid":false,"given":"Petr","family":"Menshchikov","sequence":"first","affiliation":[{"name":"Division of Medical Physics in Radiology German Cancer Research Center (DKFZ)  Heidelberg 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German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Faculty of Physics and Astronomy, Heidelberg University  Heidelberg Germany"},{"name":"Faculty of Medicine, Heidelberg University  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0244-9712","authenticated-orcid":false,"given":"Andreas","family":"Korzowski","sequence":"additional","affiliation":[{"name":"Division of Medical Physics in Radiology German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"German Cancer Consortium (DKTK), Core Center Heidelberg  Heidelberg Germany"},{"name":"Department of Cardiology Pulmonology Diseases and Vascular Medicine, Medical Faculty, Heinrich\u2010Heine\u2010University  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5914-2535","authenticated-orcid":false,"given":"Philip 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