{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:02:10Z","timestamp":1789452130558,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To improve signal strength and homogeneity of whole\u2010brain diffusion\u2010weighted imaging (DWI) at 7T.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Universal multiband excitation and refocusing pulses were optimized with the gradient ascent pulse engineering (GRAPE) algorithm across a database of  and  maps obtained from 20 subjects. Slice\u2010selective multiband pulses were optimized in a two\u2010step optimization for transverse and sagittal slice orientations. The optimized pTx pulses were compared to standard circular polarized (CP) pulses in five subjects using a multiband diffusion\u2010weighted EPI sequence at 1.5\u2009mm isotropic resolution and in one subject at 1.05\u2009mm resolution. The evaluation included Bloch simulations, flip angle mapping, SNR analysis, and diffusion model fitting (DTI and NODDI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both GRAPE pulse sets with transverse and sagittal slice orientation improved signal homogeneity and SNR compared to CP pulses across all subjects and head sizes, with particularly high gains in the cerebellum. Sagittal GRAPE pulses yielded the highest mean signal and lowest standard deviation across the brain, while transverse GRAPE pulses provided better cerebellar signal at the cost of signal loss in off\u2010resonant frontal and temporal regions of large heads. The improved signal translated into more reliable DTI and NODDI fitting, especially in the cerebellum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Universal multiband GRAPE pTx pulses substantially improve signal homogeneity and SNR in whole\u2010brain DWI at 7T, enabling more reliable diffusion microstructure mapping, particularly in the cerebellum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70588","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:02:36Z","timestamp":1789448556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole\u2010Brain Diffusion MRI at 7T With Universal Multiband GRAPE pTx Pulses"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2444-9649","authenticated-orcid":false,"given":"Marten","family":"Laufenberg","sequence":"first","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3709-9297","authenticated-orcid":false,"given":"Daniel","family":"L\u00f6wen","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Ferreira","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-2484","authenticated-orcid":false,"given":"Nicolas","family":"Boulant","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, Commissariat \u00e0 l'Energie Atomique, CNRS NeuroSpin, BAOBAB  Gif sur Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Faber","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"},{"name":"Department of Parkinson's Disease, Sleep and Movement Disorders, Center of Neurology University Hospital Bonn  Bonn Germany"},{"name":"Department of Neuroradiology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8946-9141","authenticated-orcid":false,"given":"Tony","family":"St\u00f6cker","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"},{"name":"Department of Physics &amp; 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