{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:03:24Z","timestamp":1789452204743,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["10.46540\/3103\u201000144B"],"award-info":[{"award-number":["10.46540\/3103\u201000144B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Larmor frequency shifts in white matter (WM) vary with fiber orientation due to anisotropic microstructure. Since clinical voxels are significantly larger than these microscopic frequency variations, the measured signal represents a bulk average of local shifts. Accurate estimation of magnetic susceptibility therefore requires accounting for these underlying frequency distributions that exist below the imaging resolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated whether Microstructure\u2010informed Quantitative Susceptibility Mapping (\u03bcQSM) can predict orientation\u2010dependent sub\u2010voxel frequency shifts from orientationally dispersed hollow cylinders and spherical inclusions. Diffusion\u2010weighted and multi\u2010gradient\u2010echo images were acquired from ex vivo pig optic nerves at multiple orientations relative to the main magnetic field using a 3T Siemens Connectom scanner. We also analyzed de\u2010ironed optic nerves to try and separate the effects of myelin and iron on susceptibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The estimated sub\u2010voxel frequency shifts closely matched \u03bcQSM predictions, consistent with mesoscopic field perturbations generated by uniformly magnetized axons. The de\u2010ironing experiments yielded different results depending on fixation protocol but had minimal effect on the frequency shift, indicating a negligible iron contribution to the bulk susceptibility in porcine optic nerve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\u03bcQSM accurately reproduces the orientation dependence of Larmor frequency shifts in optic nerve WM, providing insight into their microstructural origin and supporting improved estimation of tissue magnetic susceptibility in Quantitative Susceptibility Mapping.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70595","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:17:01Z","timestamp":1789449421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predicting Mesoscopic Larmor Frequency Shifts in Ex Vivo Porcine Optic Nerve"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8728-375X","authenticated-orcid":false,"given":"Anders Dyhr","family":"Sandgaard","sequence":"first","affiliation":[{"name":"Center of Functionally Integrative Neuroscience, Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"NMR Methods &amp; 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Development Group Max Planck Institute for Human Cognitive and Brain Sciences  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"Department of Neurophysics Max Planck Institute for Human Cognitive and Brain Sciences  Leipzig Germany"},{"name":"Paul Flechsig Institute \u2010 Center of Neuropathology and Brain Research, Medical Faculty University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Morawski","sequence":"additional","affiliation":[{"name":"Paul Flechsig Institute \u2010 Center of Neuropathology and Brain Research, Medical Faculty University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aage Kristian Olsen","family":"Alstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Nuclear Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5659-1925","authenticated-orcid":false,"given":"Harald E.","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"NMR Methods &amp; 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