{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:40:25Z","timestamp":1792298425326,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["21299"],"award-info":[{"award-number":["21299"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013297","name":"Eurostars","doi-asserted-by":"publisher","award":["3325"],"award-info":[{"award-number":["3325"]}],"id":[{"id":"10.13039\/100013297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Diffusion MRI has shown promise for breast cancer screening, lesion characterization, and treatment response monitoring without contrast agents, but further translation is constrained by the gradient performance of conventional systems. The aim of this work is to develop a single\u2010axis high\u2010performance bilateral plug\u2010and\u2010play breast gradient insert to enable strong\u2010gradient diffusion MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An in\u2010house breast gradient insert and bed\u2010tabletop was constructed entirely from commercially available materials, providing a cost\u2010effective solution compatible with existing MRI systems. Its wiring pattern was optimized for torque and force balancing, power dissipation, and target field performance. Evaluation included gradient field characterization, peripheral nerve stimulation simulation verification, and temperature and eddy current assessment. The setup was used for imaging of a diffusion phantom based on soy lecithin across a range of\n                      <jats:italic>b<\/jats:italic>\n                      values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Gradient efficiency ranged from 0.61 to 2.8\u2009mT\/m\/A, enabling diffusion MRI using local strengths up to 420\u2009mT\/m (150\u2009A). No peripheral nerve stimulation was observed during tests on five healthy volunteers. Eddy currents were successfully characterized, revealing a linear first order component with an amplitude of 0.03% of the applied gradient field. Imaging experiments demonstrated the feasibility of acquiring\n                      <jats:italic>b<\/jats:italic>\n                      \u2009=\u200910\u2009000\u2009s\/mm\n                      <jats:sup>2<\/jats:sup>\n                      volumes with a TE of 78\u2009ms, compared with 161\u2009ms when using the scanner gradients (40\u2009mT\/m).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This work demonstrates a dedicated bilateral breast gradient insert for safe and feasible strong\u2010gradient breast diffusion MRI and represents a first step toward dedicated hardware for breast cancer detection and characterization without contrast agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70612","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:14:46Z","timestamp":1792296886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bilateral Breast Gradient Insert Prototype for Strong Diffusion Encoding at\n                    <scp>3\u2009T<\/scp>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5644-3532","authenticated-orcid":false,"given":"Gerrit Cornelis","family":"Arends","sequence":"first","affiliation":[{"name":"Center for Image Sciences University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-3970","authenticated-orcid":false,"given":"Edwin","family":"Versteeg","sequence":"additional","affiliation":[{"name":"Center for Image Sciences University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3593-2513","authenticated-orcid":false,"given":"Feng","family":"Jia","sequence":"additional","affiliation":[{"name":"Division of Medical Physics, Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W. J.","family":"Klomp","sequence":"additional","affiliation":[{"name":"Center for Image Sciences University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim","family":"Zaitsev","sequence":"additional","affiliation":[{"name":"Division of Medical Physics, Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8190-1761","authenticated-orcid":false,"given":"Sebastian","family":"Littin","sequence":"additional","affiliation":[{"name":"Division of Medical Physics, Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal M. 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