{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:48Z","timestamp":1790927688993,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102026\u201025479556"],"award-info":[{"award-number":["RS\u20102026\u201025479556"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 EB029460"],"award-info":[{"award-number":["P41 EB029460"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AG095658"],"award-info":[{"award-number":["R21AG095658"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      The alternating unbalanced SSFP (AUSFIDE) pulse sequence, which consists of multi\u2010echo trains of SSFP\u2010FID and SSFP\u2010ECHO modules, enables rapid estimation of\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      and\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      \u2032, but is prone to errors from temporal drift of the main magnetic field (\n                      <jats:italic>B<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      ) and\n                      <jats:italic>k<\/jats:italic>\n                      \u2010space trajectory mismatch. Here, we propose a self\u2010correcting AUSFIDE method for joint correction of these two sources of error without requiring additional scans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      AUSFIDE signals were modeled in the presence of\n                      <jats:italic>B<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      drift and\n                      <jats:italic>k<\/jats:italic>\n                      \u2010space shifts. To estimate and correct for\n                      <jats:italic>B<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      drift over the entire scan, phase navigators without spatial encoding were inserted before and after each multi\u2010echo train. In addition, the intrinsic phase symmetry between SSFP\u2010FID and SSFP\u2010ECHO signals was exploited, enabling self\u2010calibration of the\n                      <jats:italic>k<\/jats:italic>\n                      \u2010space sampling trajectory. Numerical simulations and phantom experiments were performed for proof\u2010of\u2010concept validation, followed by in vivo brain imaging of 10 healthy subjects on two 3\u2009T scanners. Measured parameters were analyzed in six brain regions, and test\u2013retest reproducibility was evaluated on the two MRI platforms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Simulations and phantom imaging consistently demonstrated that\n                      <jats:italic>B<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      drift and trajectory errors resulted in image distortions and heavily overestimated\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      \u2032. Experiments further revealed that these artifacts and quantification errors were substantially reduced by the proposed self\u2010correction method. Inter\u2010scan agreement of the quantified parameters was also improved after correction on both scanners.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The self\u2010corrected AUSFIDE method is able to compensate for errors from\n                      <jats:italic>B<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      drift and\n                      <jats:italic>k<\/jats:italic>\n                      \u2010space trajectory mismatch, and thus is a potentially practical and reliable means for 3D transverse relaxometry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70619","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:21:36Z","timestamp":1790925696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Self\u2010Correction of\n                    <i>B<\/i>\n                    <scp>\n                      <sub>0<\/sub>\n                    <\/scp>\n                    Drift and Trajectory Error in Alternating Unbalanced\n                    <scp>SSFP<\/scp>\n                    \u2010\n                    <scp>FID<\/scp>\n                    and\n                    <scp>SSFP<\/scp>\n                    \u2010\n                    <scp>ECHO<\/scp>\n                    (\n                    <scp>AUSFIDE<\/scp>\n                    )\u2010Based\n                    <scp>3D<\/scp>\n                    Transverse Relaxometry of the Human Brain"],"prefix":"10.1002","author":[{"given":"Eunseo","family":"Bae","sequence":"first","affiliation":[{"name":"School of Electronic and Electrical Engineering &amp; IEDT, Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Suk","family":"Oh","sequence":"additional","affiliation":[{"name":"Medical Device Development Center, Daegu\u2013Gyeongbuk Medical Innovation Foundation (K\u2010MEDI Hub)  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyeob","family":"Han","sequence":"additional","affiliation":[{"name":"GE Healthcare  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Jaroszynski","sequence":"additional","affiliation":[{"name":"Department of Radiology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3430-1840","authenticated-orcid":false,"given":"Felix W.","family":"Wehrli","sequence":"additional","affiliation":[{"name":"Department of Radiology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-6578","authenticated-orcid":false,"given":"Hyunyeol","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Electronic and Electrical Engineering &amp; IEDT, Kyungpook National University  Daegu Republic of Korea"},{"name":"Department of Radiology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.13104\/imri.2025.0015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRev.73.679"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20104165(82)90333\u20106"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.06.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910320610"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.171.3976.1151"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.109473"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2017.12.010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103756"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.01.029"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.120189"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25232"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1996.0060"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910390312"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25610"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28637"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28262"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2025.121622"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.118952"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X231220332"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.70120"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2026.121967"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20695"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910390414"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10501"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2014.04.006"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28272"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1522\u20102594(199908)42:2<290::aid\u2010mrm11>3.0.co;2\u2010n"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24585"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25206"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21680"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334\u2010006\u20100050\u20102"},{"key":"e_1_2_9_34_1","first-page":"4207","volume-title":"Proceedings of the 26th Annual Meeting of ISMRM","author":"Rosenzweig S.","year":"2018"},{"key":"e_1_2_9_35_1","first-page":"2816","volume-title":"Proceedings of the 19th Annual Meeting of ISMRM","author":"Block K. T.","year":"2011"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910150117"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1109\/TSP.2002.807005"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"e_1_2_9_39_1","volume-title":"Statistical Parametric Mapping: The Analysis of Functional Brain Images","author":"Penny W. D.","year":"2011"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2025.109067"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.051"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.210.3.r99fe41759"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.11.057"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21108"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074795"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.03.022"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522\u20102586(200102)13:2<308::AID\u2010JMRI1044>3.0.CO;2\u2010L"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27985"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25860"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350305"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25114"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24202"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1109\/ISBI.2010.5490076"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1998.1396"},{"key":"e_1_2_9_55_1","first-page":"3102","volume-title":"Proceedings of the 18th Annual Meeting of ISMRM","author":"Magland J. F.","year":"2010"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2020.2978405"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.70619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrm.70619","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.70619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:21:38Z","timestamp":1790925698000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.70619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":55,"alternative-id":["10.1002\/mrm.70619"],"URL":"https:\/\/doi.org\/10.1002\/mrm.70619","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]},"assertion":[{"value":"2026-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"mrm.70619"}}