{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:48:31Z","timestamp":1791611311950,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006474","name":"Columbia University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006474","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21MH143119"],"award-info":[{"award-number":["R21MH143119"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21HD122301"],"award-info":[{"award-number":["R21HD122301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Brain MR elastography (MRE) is uniquely sensitive to subject motion, as even small phase deviations can produce large errors in the mechanical properties estimated. Existing motion correction strategies have not been validated for MRE and are often incompatible with complex multi\u2010shot or joint temporal reconstructions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We propose COMET (Correction Of Motion in Elastography via Transformation), a framework that estimates rigid\u2010body motion from navigator images and embeds transformation matrices into an iterative reconstruction and displacement\u2010vector reorientation for multi\u2010shot MRE. We additionally validate post\u2010reconstruction correction and displacement\u2010vector reorientation for single\u2010shot MRE. The framework was evaluated on MRE from 9 pairs of EPI single\u2010shot and 9 pairs of spiral multi\u2010shot acquisitions, each containing a with\u2010motion scan and a reference. Additionally, four representative motion patterns with increasing amplitude were simulated to indicate how different motions affect MRE quality and results, and a brain tumor MRE dataset with simulated motion was used to assess clinical effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Motion correction improved stiffness accuracy across all tested datasets, reducing average stiffness errors by up to 240.86% in multi\u2010shot spiral MRE, and by up to 44.28% in single\u2010shot EPI, across in vivo motion ranging from 4.81 to 67.58\u2009mm translation and 1.85\u00b0\u201323.63\u00b0 rotation. In a pediatric glioma dataset, simulated motion completely obscured tumor stiffness contrast, while correction restored tumor stiffness visibility. Robustness of estimated stiffness maps depended on motion amplitude, temporal motion patterns, and encoding strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This approach enables robust motion correction for single\u2010 and multi\u2010shot brain MRE, and expands reliable MRE to clinical and challenging populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70625","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:51:23Z","timestamp":1791607883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iterative Navigator\u2010Based Retrospective Motion Correction for Multi\u2010Shot Brain\n                    <scp>MR<\/scp>\n                    Elastography and Evaluation of Single\u2010Shot Post\u2010Reconstruction Correction"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0642-9153","authenticated-orcid":false,"given":"Zhuoyu","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Fu Foundation School of Engineering and Applied Science Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex Michael","family":"Cerjanic","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6594-8757","authenticated-orcid":false,"given":"Grace","family":"McIlvain","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Fu Foundation School of Engineering and Applied Science Columbia University  New York New York USA"},{"name":"Department of Radiology, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010024\u201003491\u2010z"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.117889"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010016\u20101767\u2010x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4754649"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073820909274"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28211"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12806"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21883"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010019\u201002160\u2010w"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28959"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29976"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29961"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24314"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29534"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26796"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25516"},{"key":"e_1_2_10_18_1","volume-title":"Proceedings of the Annual Meeting of ISMRM","author":"Johnson C. 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