{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:46:54Z","timestamp":1791964014050,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010133","name":"Aarne Koskelon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007634","name":"Ida Montinin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007361","name":"Aarne ja Aili Turusen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005633","name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      This study aimed to investigate the applicability of rotating frame spin\u2010lock continuous wave (CW) T\n                      <jats:sub>1\u03c1<\/jats:sub>\n                      and relaxation along a fictitious field with Rank 2 (RAFF2) methods complementary to native T\n                      <jats:sub>1<\/jats:sub>\n                      and late gadolinium enhancement (LGE) for cardiac magnetic resonance imaging (CMRI) of diffuse fibrosis in mice with advancing hypertensive heart disease (HHD) and diastolic dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      HHD was induced in mice with angiotensin II infusion for 28\u2009days; sham operated were used as controls. Phenotype progression was assessed with echocardiography. Characterization of diffuse fibrosis was performed with CMRI. CW\u2010T\n                      <jats:sub>1\u03c1<\/jats:sub>\n                      and RAFF2 were compared with native T\n                      <jats:sub>1<\/jats:sub>\n                      and LGE acquired on Days 14 and 28 of the experiment. Regions of interest in CMRI relaxation time maps and Picrosirius red\u2010stained histological cardiac sections were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Diffuse fibrosis in the left ventricle was visible on Day 14 with T\n                      <jats:sub>RAFF2<\/jats:sub>\n                      relaxation time maps in the HHD group with early diastolic impairment, and CW\u2010T\n                      <jats:sub>1\u03c1<\/jats:sub>\n                      showed a slight increase. Both CW\u2010T\n                      <jats:sub>1\u03c1<\/jats:sub>\n                      and T\n                      <jats:sub>RAFF2<\/jats:sub>\n                      showed elevated values on Day 28 in HHD mice, whereas native T\n                      <jats:sub>1<\/jats:sub>\n                      showed an increase only on Day 28. LGE showed no accumulation. The presence of diffuse fibrosis was verified with cardiac histology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Rotating frame spin\u2010lock CW\u2010T\n                      <jats:sub>1\u03c1<\/jats:sub>\n                      and RAFF2 are more sensitive to native T\n                      <jats:sub>1<\/jats:sub>\n                      and LGE in the characterization of diffuse fibrosis in advancing HHD in mice, being an alternative for the imaging of fibrotic remodeling also in other cardiac pathologies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70636","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:10:03Z","timestamp":1791961803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rotating Frame Spin\u2010Lock Cardiac\n                    <scp>MRI<\/scp>\n                    Method at 9.4\u2009T Can Characterize Diffuse Fibrosis in Progressing Hypertensive Heart Disease in Mice"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6349-9625","authenticated-orcid":false,"given":"Riku","family":"Kiviluoto","sequence":"first","affiliation":[{"name":"A.I. Virtanen Institute for Molecular Sciences University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"T\u00f6rm\u00e4","sequence":"additional","affiliation":[{"name":"A.I. Virtanen Institute for Molecular Sciences University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Tawfek","sequence":"additional","affiliation":[{"name":"A.I. Virtanen Institute for Molecular Sciences University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksi","family":"Leikas","sequence":"additional","affiliation":[{"name":"A.I. Virtanen Institute for Molecular Sciences University of Eastern Finland  Kuopio Finland"},{"name":"Department of Medicine University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eetu","family":"R\u00e4ih\u00e4","sequence":"additional","affiliation":[{"name":"A.I. Virtanen Institute for Molecular Sciences University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Merentie","sequence":"additional","affiliation":[{"name":"Heart Hospital Nova Wellbeing Services County of Central Finland  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Kaisa","family":"Ruotsalainen","sequence":"additional","affiliation":[{"name":"A.I. Virtanen Institute for Molecular Sciences University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Yl\u00e4\u2010Herttuala","sequence":"additional","affiliation":[{"name":"A.I. Virtanen Institute for Molecular Sciences University of Eastern Finland  Kuopio Finland"},{"name":"Heart Center and Gene Therapy Unit Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Yl\u00e4\u2010Herttuala","sequence":"additional","affiliation":[{"name":"A.I. Virtanen Institute for Molecular Sciences University of Eastern Finland  Kuopio Finland"},{"name":"Clinical Radiology Unit, Imaging Center Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/HYPERTENSIONAHA.119.14240","article-title":"High Blood Pressure and Cardiovascular Disease","volume":"75","author":"Fuchs F. D.","year":"2020","journal-title":"Hypertension"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global Burden of Cardiovascular Diseases and Risk Factors, 1990\u20132019","volume":"76","author":"Roth G. 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