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Interviews were recorded, transcribed and analysed using \u2018framework\u2019 analysis. Ethical approval was obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three themes emerged: patterns and causes, consequences and management of fatigue. While patients\u2019 descriptions of fatigue were similar, the patterns and perceived causes of fatigue varied between individuals. Fatigue impacted on social life, relationships and work. Two approaches to fatigue management were observed: help and support from others and self\u2010management, with four participants having sought medical help for fatigue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study suggested that fatigue has a negative impact on quality of life in people with AS. Future practice should include a comprehensive fatigue assessment and the development of treatment programmes directed at enhancing self\u2010management techniques. 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