{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:35:59Z","timestamp":1768822559275,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Musculoskeletal Care"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the present study was to report on factors associated with changes in disability after 5\u00a0years, with a focus on physical activity (PA) in community\u2010dwelling older adults with generalized radiographic osteoarthritis (GROA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Assessment of GROA (hand, knee, hip) and disability (Health Assessment Questionnaire) in the Rotterdam Study (cohort RS\u20101, <jats:italic>N<\/jats:italic>\u00a0=\u00a07,983; with GROA, <jats:italic>n<\/jats:italic>\u00a0=\u00a0821). A good outcome at follow\u2010up was defined as improved or mild disability, and a poor outcome as worsened or severe disability. Factors potentially associated with outcome were demographics, joint complaints, other chronic health problems or limitations (body mass index, number of chronic conditions, cognition), and level of different types of PA. Some of these assessments were repeated in between 1997 and 1999 (RS\u20103), and between 2002 and 2004 (RS\u20104).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 309 older adults with GROA and valid measures on RS\u20103 and RS\u20104 showed mild to moderate disability, with minor increases over 5\u00a0years (follow\u2010up <jats:italic>N<\/jats:italic>\u00a0=\u00a0287 RS\u20103 to RS\u20104). PA levels decreased with increasing disability, especially in sport and walking. PA was univariately associated with a better outcome at follow\u2010up but when adjusted for other factors (higher age, having knee pain and stiffness, and having more than two other chronic conditions) was associated with negative changes in general and lower limb disability, although not with upper limb disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This was the first study to report that community\u2010dwelling older adults with GROA show moderate levels of disability, and that reduced levels of disability are associated with higher levels of PA, but when adjusted for other confounders this association is lost. Further research is needed to study the complex relationships between PA and other determinants of disability.<\/jats:p><\/jats:sec>","DOI":"10.1002\/msc.1182","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T11:58:49Z","timestamp":1491825529000},"page":"364-372","source":"Crossref","is-referenced-by-count":10,"title":["Changes in disability in older adults with generalized radiographic osteoarthritis: A complex relationship with physical activity"],"prefix":"10.1002","volume":"15","author":[{"given":"E.C.P.M.","family":"Tak","sequence":"first","affiliation":[{"name":"Netherlands Organization for Applied Scientific Research TNO, Research Center Body@Work TNO VUmc  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.B.","family":"van Meurs","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Erasmus Medical Center  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.M.A.","family":"Bierma\u2010Zeinstra","sequence":"additional","affiliation":[{"name":"Department of General Practice Erasmus Medical Centre  Rotterdam the Netherlands"},{"name":"Department of Orthopaedics Erasmus Medical Centre  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hofman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus Medical Centre  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hopman\u2010Rock","sequence":"additional","affiliation":[{"name":"Netherlands Organization for Applied Scientific Research TNO, Research Center Body@Work TNO VUmc  Leiden the Netherlands"},{"name":"Department of Public and Occupational Health\/EMGO Institute for Health and Care Research (EMGO+) VU University Medical Center  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199301000-00011"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0423"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20695"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.11.1040"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115821"},{"key":"e_1_2_5_7_1","first-page":"1938","article-title":"Generalized osteoarthritis in women: Pattern of joint involvement and approaches to definition for epidemiological studies","volume":"23","author":"Cooper C.","year":"1996","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/31.5.325"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21375"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.017087"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1999.0272"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2010.01.015"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-8-200010170-00016"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004376.pub2","article-title":"Exercise for osteoarthritis of the knee","volume":"4","author":"Fransen M.","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_5_16_1","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD007912","article-title":"Exercise for osteoarthritis of the hip","volume":"3","author":"Fransen M.","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_5_17_1","first-page":"789","article-title":"The dimensions of health outcomes: The health assessment questionnaire, disability and pain scales","volume":"9","author":"Fries J. 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