{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:41:09Z","timestamp":1793144469782,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Musculoskeletal Care"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment adherence is an important medical and pharmaco\u2010economical phenomenon, influenced by multiple variables. Treatment adherence in systemic sclerosis (SSc) has been poorly studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the present study was to assess treatment adherence in SSc patients and to identify factors associated with good and poor adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a monocentric, cross\u2010sectional, observational study. Treatment adherence was evaluated by the Compliance Questionnaire of Rheumatology (CQR). The necessity of treatment and concerns about treatment were investigated using the Beliefs about Medicines Questionnaire\u2010Specific (BMQ\u2010S). The Illness Perception Questionnaire\u2010Revised (IPQ\u2010R) assessed illness perceptions. Disease\u2010related characteristics were collected retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 66 patients were enrolled in this study. Of these, 47 (71.2%) had a weighted CQR score of \u226480% (\u201cpoor adherence\u201d) and 19 (28.8%) had a weighted CQR score of &gt;80% (\u201cgood adherence\u201d). No significant relationship between demographic, clinical or psychological factors and overall adherence could be found, except with the IPQ subscale \u201ctimeline acute\/chronic\u201d (<jats:italic>p<\/jats:italic> = 0.042). Our patient population estimated the necessity of their medication high (mean necessity score 20.5), with moderate concern beliefs (mean concern score 15.1). Subjective adherence, as self\u2010reported by patients, was high.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated low treatment adherence rates in SSc patients. We could not identify demographic, clinical or psychological factors associated with treatment adherence, except with the IPQ subscale \u201ctimeline acute\/chronic\u201d. This suggests a correlation between poor adherence and the belief that the disease will be chronic without improvement over time. Symptom relief was an important motivating factor for taking medication. The treatment necessity was scored higher than treatment concerns, but the necessity beliefs were not associated with adherence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/msc.1363","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T09:39:40Z","timestamp":1539077980000},"page":"44-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Treatment adherence in systemic sclerosis: A cross\u2010sectional study"],"prefix":"10.1002","volume":"17","author":[{"given":"Jan","family":"Brijs","sequence":"first","affiliation":[{"name":"Faculty of Medicine University Hospitals Leuven  KU Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seher","family":"Arat","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University Hospitals Leuven  KU Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Westhovens","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University Hospitals Leuven  KU Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Leo","family":"Lenaerts","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University Hospitals Leuven  KU Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4045-2146","authenticated-orcid":false,"given":"Ellen","family":"De Langhe","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University Hospitals Leuven  KU Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-0407.2012.00183.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jegh.2014.05.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/msc.223"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2017.10.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2004.11.010"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v4.i2.30"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.05.003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-006-9026-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-017-9906-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4045-y"},{"issue":"11","key":"e_1_2_7_12_1","first-page":"2469","article-title":"The Compliance\u2010Questionnaire\u2010Rheumatology compared with electronic medication event monitoring: A validation study","volume":"30","author":"Klerk E.","year":"2003","journal-title":"Journal of Rheumatology"},{"issue":"12","key":"e_1_2_7_13_1","first-page":"2635","article-title":"Development of a questionnaire to investigate patient compliance with antirheumatic drug therapy","volume":"26","author":"Klerk E.","year":"1999","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1160-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-016-0919-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0806188"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0816-6"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.01.011"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/08870446.2012.685740"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/msc.27"},{"key":"e_1_2_7_21_1","unstructured":"Horne R. Weinman J. Barber N. &Elliott R.(2005).Concordance adherence and compliance in medicine taking. Report for the National Co\u2010Ordinating Centre for NHS Service Delivery and Organisation R & D (NCCSDO) 1\u2013331. 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