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Disease manifestations such as arthritis, orogenital ulcerations, rashes, angiitis, and neurological involvement affect health\u2010related quality of life (HRQoL) through its impact on depression, anxiety, and fatigue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed explore the psychological impact of BD, taking into consideration the effect on the HRQoL, as well as the association with depression, anxiety, wellbeing, and fatigue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a narrative review of the literature that looks into the association of BD on the HRQoL including all studies that have assessed such as association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results\/Findings<\/jats:title><jats:p>Depression and anxiety are prevalent among patients with BD, and contribute significantly to fatigue, a common symptom among BD patients. In addition, the psychological wellbeing is affected by the disease, however, more studies are needed to assess this relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Depression and anxiety are strongly associated with BD, and contribute significantly to fatigue, a common symptom among BD patients. In addition, the psychological wellbeing is affected by the disease, however, more studies are needed to assess this relationship. 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