{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:42:36Z","timestamp":1793724156836,"version":"4.6.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Musculoskeletal Care"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the golimumab retention rate during up to 8\u00a0years of follow up, and any associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of the BIOBADASER (Spanish registry of biological drugs) database, assessing all adults who had ever started golimumab &gt;6\u00a0months before the analysis for an approved indication (rheumatoid arthritis [RA], axial spondyloarthritis [SpA] or psoriatic arthritis [PsA]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 885 patients (RA 267, axial SpA 370, PsA 248) receiving 944 cycles of golimumab, the retention rate of golimumab was 71.1% (95% confidence interval: 68.0\u201373.9) at year 1% and 37.7% (95% CI: 33.3\u201342.1) at year 7 and at year 8. Retention was higher when golimumab was used as the first biological drug (81.7% at year 1, 49.9% at year 7,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). In Cox regression analysis, factors associated with golimumab retention included use as first\u2010line therapy (hazard ratio [HR] for discontinuation 1.52 for second\u2010 and 1.79 for third\/later\u2010line vs. first\u2010line), use in axial SpA or PsA rather than RA (HR for axial SpA vs. RA 0.59, for PsA vs. Rheumatoid arthritis 0.67), and treatment with concomitant methotrexate (HR 0.67). Factors associated with golimumab discontinuation were corticosteroid use (HR 1.46) and disease activity above median (HR 1.29) at golimumab initiation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Based on this retrospective analysis of the BIOBADASER registry, nearly two\u2010fifths (37.7%) of adult rheumatology patients initiating golimumab will remain on treatment for 8\u00a0years, with a higher probability of retention in axial SpA or PsA indications and when golimumab is used as first biologic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/msc.1684","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T01:52:10Z","timestamp":1661219530000},"page":"189-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Long\u2010term retention 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