{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:34:10Z","timestamp":1789756450794,"version":"4.0.1"},"reference-count":78,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Musculoskeletal Care"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriatic arthritis (PsA) is a chronic inflammatory arthritis characterised by musculoskeletal and extra\u2010articular manifestations, most notably psoriasis. While the underlying pathogenetic mechanisms are not yet fully understood, a central role has been identified for the IL\u201023\/IL\u201017 pathway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We briefly describe the role of IL\u201023 in the pathogenesis of PsA and go on to describe the available anti\u2010IL\u201023 agents and their place in the management of PsA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a narrative review of the current literature, focussing on the results of the phase 3 studies in PsA for the IL\u201012\/23 p40 inhibitor ustekinumab and\u00a0the more recent IL\u201023 p19 inhibitors guselkumab, risankizumab and tildrakizumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IL\u201023 triggers expression of IL\u201017 and other effector cytokines in a variety of cells, leading to tissue inflammation and injury. Targeting IL\u201023, particularly with p19 inhibitors, appears to be an effective and safe strategy for multiple clinical domains in PsA, most notably the skin, with some differences in efficacy emerging between these agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The development of IL\u201023 inhibitors represents a significant advance in the management of psoriatic disease. In the absence of head\u2010to\u2010head studies, future data emerging from real\u2010world experiences of individual IL\u201023 p19 inhibitors will help inform the use of these agents in relation to other biologics in PsA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/msc.1694","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T08:45:38Z","timestamp":1662540338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The role of IL\u201023 and the use of IL\u201023 inhibitors in psoriatic arthritis"],"prefix":"10.1002","volume":"20","author":[{"given":"George E.","family":"Fragoulis","sequence":"first","affiliation":[{"name":"Joint Rheumatology Program National and Kapodistrian University of Athens  Athens Greece"},{"name":"School of Infection and Immunity University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Siebert","sequence":"additional","affiliation":[{"name":"School of Infection and Immunity University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37937"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.05.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","unstructured":"Armstrong A. W. Puig L. Joshi A. Skup M. Williams D. Li J. Betts K. A. &Augustin M.(2020).Comparison of biologics and oral treatments for plaque psoriasis: A meta\u2010analysis.JAMA Dermatol 156(3) 258\u2013269.https:\/\/doi.org\/10.1001\/jamadermatol.2019.4029","DOI":"10.1001\/jamadermatol.2019.4029"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102018\u2010213328"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38995"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21743"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.041"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010221422"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102018\u2010214944"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201065269\u20106"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010220991"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010022\u201000798\u20100"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057553"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102019\u2010215210"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40728"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30265\u20108"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez457"},{"key":"e_1_2_8_19_1","unstructured":"Fierce Biotech. (2021).Lilly scraps IL\u201023 psoriasis program despite phase 3 success focuses on IBD race against AbbVie J&J. Retrieved 27 July 2022 fromwww.fiercebiotech.com\/biotech\/lilly\u2010scraps\u2010il\u201023\u2010psoriasis\u2010program\u2010despite\u2010phase\u20103\u2010success\u2010focuses\u2010ibd\u2010race\u2010against"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X20976975"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/8zn9z8"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010med\u2010051914\u2010021944"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3707"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00184\u20107"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.33.1.150"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067\u2010021\u201005774\u20109"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06589-y"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31713\u20106"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102020\u2010217159"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010221640"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102015\u2010208902"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010020\u20100486\u20101"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810652"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen\u20102019\u2010001149"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102011\u2010301668"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102016\u2010209853"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22645"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102013\u2010204741"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.08.004"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010221019"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.05.1013"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.09.003"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(08)60725\u20104"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.594735"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen\u20102020\u2010001450"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(13)60594\u20102"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42010"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102020\u2010219014"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2665\u20109913(21)00105\u20103"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30263\u20104"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.01.005"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen\u20102018\u2010000656"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010221048"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjab185"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9092044"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X211057975"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)31773\u20108"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1505557"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen\u20102022\u2010002195"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102013\u2010204655"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1900750"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220868"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-022-00444-x"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010022\u201000776\u20106"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjac034"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab461"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2817"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010221799"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000719"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102018\u2010213654"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010220263"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen\u20102021\u2010001679"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.298"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen\u20102018\u2010000779"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000254"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01550"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40770"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.596086"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.2909"}],"container-title":["Musculoskeletal Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/msc.1694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/msc.1694","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/msc.1694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T10:10:39Z","timestamp":1692612639000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/msc.1694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,7]]},"references-count":78,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/msc.1694"],"URL":"https:\/\/doi.org\/10.1002\/msc.1694","archive":["Portico"],"relation":{},"ISSN":["1478-2189","1557-0681"],"issn-type":[{"value":"1478-2189","type":"print"},{"value":"1557-0681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,7]]},"assertion":[{"value":"2022-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}