{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:46:10Z","timestamp":1761767170703,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Musculoskeletal Care"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Pain in rheumatoid arthritis (RA) is considered to be associated with non\u2010inflammatory factors, including physical disabilities, psychiatric disorders, and pain catastrophizing (PC). PC is reportedly a key driver in the development of pain in patients with RA without clinical signs of inflammation; however, previous studies enroled patients with RA who were potentially in an inflammatory state. Hence, our aim was to investigate the role of PC as the possible link between pain, physical disabilities, and psychiatric disorders in patients with RA without clinical signs of inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this cross\u2010sectional study, 81 patients with RA without clinical signs of inflammation were included; all patients had serum C\u2010reactive protein levels &lt;0.5\u00a0mg\/dL, without any inflammatory joints. We examined the demographic and clinical data and administered the pain visual analogue scale (VAS), pain catastrophizing scale (PCS), Health Assessment Questionnaire Disability Index (HAQ\u2010DI), and patient version of the Brief Scale for Psychiatric Problems in Orthopaedic Patients (pBS\u2010POP). A series of multivariate\u2010adjusted multiple regression analyses were performed to examine the associations between PC and pain intensity, physical disabilities, and psychiatric disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found associations between all the above\u2010mentioned variables in separate models with HAQ\u2010DI, pBS\u2010POP, and PCS scores. However, in the model associated with pain VAS, the PCS score (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.34, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0073) emerged as the only variable showing a statistically significant association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PC is associated with pain in patients with RA without clinical signs of inflammation, and this association may be mediated through pathways involving physical disabilities and psychiatric disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/msc.1740","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T13:33:27Z","timestamp":1675776807000},"page":"694-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The role of pain catastrophizing in pain perception among patients with rheumatoid arthritis without clinical signs of inflammation"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1783-8355","authenticated-orcid":false,"given":"Takeo","family":"Abe","sequence":"first","affiliation":[{"name":"Division of Diabetes, Endocrinology and Clinical Immunology Department of Internal Medicine Hyogo Medical University  Nishinomiya Hyogo Japan"},{"name":"Department of Rheumatology Medicine Kobe City Medical Center West Hospital  Kobe\u2010shi Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Tamura","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Clinical Immunology Department of Internal Medicine Hyogo Medical University  Nishinomiya Hyogo Japan"},{"name":"Department of Rheumatology Medicine Kobe City Medical Center West Hospital  Kobe\u2010shi Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Azuma","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Clinical Immunology Department of Internal Medicine Hyogo Medical University  Nishinomiya Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Matsui","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Clinical Immunology Department of Internal Medicine Hyogo Medical University  Nishinomiya Hyogo 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