{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:07:27Z","timestamp":1792030047296,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T00:00:00Z","timestamp":1685145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Musculoskeletal Care"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine factors associated with fatigue in patients with rheumatoid arthritis (RA), and to identify baseline predictors of persistent fatigue at 12\u00a0months of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enroled patients with RA fulfiling the 2010 American College of Rheumatology\/European League Against Rheumatism criteria. Fatigue was assessed using the Arabic version of the Functional Assessment of Chronic Illness Therapy\u2014Fatigue (FACIT\u2010F). Using univariate and multivariate analyses, we examined baseline variables associated with fatigue and persistent fatigue (if the FACIT\u2010F score was less than 40 at baseline and 12\u00a0months of follow\u2010up).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 100 RA patients of whom 83% reported fatigue. At baseline, the FACIT\u2010F score was significantly associated with older age (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007), pain (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), global patient assessment (GPA) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), tender joint count (TJC) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), swollen joint count (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003), erythrocyte sedimentation rate (ESR)\u00a0(<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), disease activity score (DAS28 ESR) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), and health assessment questionnaire (HAQ) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). At 12\u00a0months of follow\u2010up, the percentage of patients who reported persistent fatigue was 60%. The FACIT\u2010F score was significantly associated with age (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.015), symptom duration (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), pain (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), GPA (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), TJC (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), C\u2010Reactive Protein (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007), ESR (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.009), DAS28 ESR (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), and HAQ (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Pain was an independent baseline predictor of persistent fatigue (OR\u00a0=\u00a00.969 (95% CI [0.951\u20130.988]), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fatigue is a frequent symptom in RA. Pain, GPA, disease activity and disability were associated with fatigue and persistent fatigue. Baseline pain was the only independent predictor of persistent fatigue.<\/jats:p><\/jats:sec>","DOI":"10.1002\/msc.1787","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T13:33:57Z","timestamp":1685194437000},"page":"1068-1074","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Baseline predictors of fatigue and persistent fatigue in rheumatoid arthritis: A longitudinal observational study"],"prefix":"10.1002","volume":"21","author":[{"given":"Alia","family":"Fazaa","sequence":"first","affiliation":[{"name":"Department of Rheumatology Mongi Slim University Hospital  Tunis Tunisia"},{"name":"University of Tunis El Manar Faculty of Medicine of Tunis  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4744-5766","authenticated-orcid":false,"given":"Hiba","family":"Boussaa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Mongi Slim University Hospital  Tunis Tunisia"},{"name":"University of Tunis El Manar Faculty of Medicine of Tunis  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kmar","family":"Ouenniche","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Mongi Slim University Hospital  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3596-8025","authenticated-orcid":false,"given":"Saoussen","family":"Miladi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Mongi Slim University Hospital  Tunis Tunisia"},{"name":"University of Tunis El Manar Faculty of Medicine of Tunis  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8788-0626","authenticated-orcid":false,"given":"Yasmine","family":"Makhlouf","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Mongi Slim University Hospital  Tunis Tunisia"},{"name":"University of Tunis El Manar Faculty of Medicine of Tunis  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salwa","family":"Belhadj","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Mongi Slim University Hospital  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kawther","family":"Ben Abdelghani","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Mongi Slim University Hospital  Tunis Tunisia"},{"name":"University of Tunis El Manar Faculty of Medicine of Tunis  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Laatar","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Mongi Slim University Hospital  Tunis Tunisia"},{"name":"University of Tunis El Manar Faculty of Medicine of Tunis  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2019.10.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41687\u2010019\u20100105\u20106"},{"issue":"5","key":"e_1_2_10_5_1","first-page":"811","article-title":"Validation of the functional assessment of chronic illness therapy fatigue scale relative to other instrumentation in patients with rheumatoid arthritis","volume":"32","author":"Cella D.","year":"2005","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102022\u2010222517"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.141498"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2018.07.010"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq282"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22611"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010220750"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00021"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926\u2010017\u20100649\u20105"},{"issue":"5","key":"e_1_2_10_14_1","first-page":"1174","article-title":"Patient perspective: Fatigue as a recommended patient centered outcome measure in rheumatoid arthritis","volume":"34","author":"Kirwan J. 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