{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:34:55Z","timestamp":1783568095206,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Musculoskeletal Care"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Axial spondyloarthritis (axSpA) is a chronic inflammatory disease with heterogeneous clinical manifestations, including extra\u2010articular manifestations (EAMs) such as acute anterior uveitis (AAU), inflammatory bowel disease (IBD), and psoriasis. This study aimed to assess the impact of EAMs on disease characteristics in axSpA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was conducted in a Moroccan rheumatology department over 12\u00a0years. Patients diagnosed with axSpA according to ASAS 2009 criteria were included. Those with at least one EAM were compared with those without EAMs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 400 axSpA patients (54% women, mean age 45.84\u00a0\u00b1\u00a014.42\u00a0years, median disease duration 7.49\u00a0\u00b1\u00a06.89\u00a0years). EAMs were observed in 30.3%. The three commonest EAMs were IBD (18.5%), AAU (12.5%) and psoriasis (2%). Compared with those without EAMs, patients with EAMs had significantly longer disease duration (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014), more frequent cervical pain (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.040), thoracic back pain (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.043), spinal stiffness (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), and buttock pain (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.024). They also exhibited more radiographic sacroiliitis (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), higher disease activity (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.05), and worse physical function (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004). Nonsteroidal anti\u2010inflammatory drugs use was less frequent (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.021), whereas sulfasalazine (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.043) and TNF\u2010\u03b1 inhibitors (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) were more commonly used. Worse physical function (BASFI) was the main independent factor associated with EAMs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EAMs, particularly IBD and AAU, are prevalent in axSpA. Their presence significantly affects clinical outcomes and patient\u2010reported measures, highlighting their importance in disease management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/msc.70087","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T08:28:06Z","timestamp":1743323286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Burden of Extra\u2010Articular Manifestations in Axial Spondyloarthritis: A Moroccan Single\u2010Centre Study"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7094-0105","authenticated-orcid":false,"given":"Khaoula","family":"Tahir","sequence":"first","affiliation":[{"name":"Rheumatology Department Hassan II University Medical Center Fez Faculty of Medicine and Pharmacy and Dentistry of Fez University Sidi Mohammed Ben Abdellah  Fez Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nessrine","family":"Akasbi","sequence":"additional","affiliation":[{"name":"Rheumatology Department Hassan II University Medical Center Fez Faculty of Medicine and Pharmacy and Dentistry of Fez University Sidi Mohammed Ben Abdellah  Fez Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imane","family":"El Mezouar","sequence":"additional","affiliation":[{"name":"Rheumatology Department Hassan II University Medical Center Fez Faculty of Medicine and Pharmacy and Dentistry of Fez University Sidi Mohammed Ben Abdellah  Fez Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoufik","family":"Harzy","sequence":"additional","affiliation":[{"name":"Rheumatology Department Hassan II University Medical Center Fez Faculty of Medicine and Pharmacy and Dentistry of Fez University Sidi Mohammed Ben Abdellah  Fez Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573397115666190222195923"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067\u2010016\u20103261\u20106"},{"key":"e_1_2_10_4_1","first-page":"282","article-title":"Radiographic Axial Versus Non\u2010Radiographic Axial Spondyloarthritis: Comparison of the Disease Activity Parameters and the Disease Activity and Functional Scores: RBSMR Study","volume":"14","author":"Bench\u00e9rifa S.","year":"2019","journal-title":"International Journal of Clinical Rheumatology"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.230929rtm"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.05.017"},{"key":"e_1_2_10_7_1","first-page":"2667","article-title":"Inflammatory Eye, Skin, and Bowel Disease in Spondyloarthritis: Genetic, Phenotypic, and Environmental Factors","volume":"28","author":"Brophy S.","year":"2001","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067\u2010006\u20100403\u20102"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rhum.2012.04.012"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen\u20102020\u2010001206"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.06.006"},{"issue":"1","key":"e_1_2_10_12_1","first-page":"32","article-title":"Extra\u2010articular Manifestations and Burden of Disease in Patients With Radiographic and Non\u2010Radiographic Axial Spondyloarthritis","volume":"43","author":"Erol K.","year":"2018","journal-title":"Acta Reumatologica Portuguesa"},{"key":"e_1_2_10_13_1","first-page":"214","article-title":"Do Extra\u2010Articular Manifestations Influence Outcome in Ankylosing Spondylitis? 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