{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:22:30Z","timestamp":1774614150332,"version":"3.50.1"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Musculoskeletal Care"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Chronic nonspecific neck pain (CNNP) is a multifactorial condition associated with pain\u2010related emotional impact and sleep disturbance. Its impact on health\u2010related quality of life (HRQoL) in non\u2010Western populations remains understudied. This cross\u2010sectional study examined associations between disability, pain, sleep, pain\u2010related emotional and social factors, and HRQoL in Iranian adults with CNNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults with CNNP were recruited from tertiary rehabilitation centres in Tehran. Of 135 screened, 107 were analysed. Instruments included the NDI, NPDS, VAS, PSQI, and SF\u201036. Spearman's correlation, multivariable regression, and bootstrapped indirect\u2010association analyses were used to identify factors associated with HRQoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants exhibited moderate disability (NDI 17.2\u00a0\u00b1\u00a06.5; NPDS 48.1\u00a0\u00b1\u00a016.5) and poor sleep (PSQI 6.4\u00a0\u00b1\u00a03.7). Pain was correlated with disability (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a00.44), sleep dysfunction (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a00.55), and lower SF\u201036 scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Sleep disturbance was the primary independent factor associated with reduced Vitality, Mental Health, and Social Functioning, while sleep latency further contributed to lower Vitality; together, these variables explained 28%\u201349% of the variance across these domains (adjusted\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.28\u20130.49). Lifting difficulty and pain with walking predicted poorer Physical Functioning, and lifting difficulty also predicted greater Bodily Pain. Difficulty working overhead uniquely contributed to lower General Health. Pain interference with work contributed to reduced Physical Functioning, while daytime dysfunction was associated with Bodily Pain. A BMI\u00a0\u2265\u00a025\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      was associated with greater pain severity, poorer sleep, and lower HRQoL. A more negative Pain\u2010Related Outlook on Life\/Future was linked to lower Vitality, and pain\u2010related emotional impact corresponded to reduced Mental Health. No severe multicollinearity or construct redundancy was detected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CNNP was associated with disability, sleep disturbance, and pain\u2010related emotional and social interference, each contributing independently to reduced HRQoL. Findings support the importance of individualised, multidisciplinary rehabilitation strategies incorporating biomechanical, sleep\u2010focused, and psychological interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/msc.70206","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T18:55:40Z","timestamp":1774119340000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional, Sleep\u2010Related, and Pain\u2010Related Emotional and Social Factors Associated With Health\u2010Related Quality of Life in Chronic Nonspecific Neck Pain: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5240-1484","authenticated-orcid":false,"given":"Hossein","family":"Safaei","sequence":"first","affiliation":[{"name":"Department of Sports and Exercise Medicine, School of Medicine Hazrat\u2010e Rasool General Hospital Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chakavak","family":"Valadkhani","sequence":"additional","affiliation":[{"name":"Department of Sports and Exercise Medicine, School of Medicine Hazrat\u2010e Rasool General Hospital Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyede Zahra Emami","family":"Razavi","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Imam Khomeini Hospital Tehran University of Medical Sciences  Tehran Iran"},{"name":"Joint Reconstruction Research Center (JRRC) Imam Khomeini Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6860-0403","authenticated-orcid":false,"given":"Mohaddeseh","family":"Azadvari","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Sina Hospital Tehran University of Medical Sciences  Tehran Iran"},{"name":"Urology Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3233\/OER\u20102012\u20100200"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217231"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.42.3.20200768"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100916"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.15386\/cjmed\u2010749"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0254262"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701\u2010013\u20101909\u20104"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13984"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891\u2010020\u20103080\u20104"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000466"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000711"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891\u2010023\u201006721\u20102"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2010.02.007"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2016.08.004"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874325001307010521"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010019\u20100505\u2010y"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18020460"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12842"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0324101"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325\u2010010\u20100478\u20105"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12444"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/OER\u20102008\u20108105"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102019\u2010033946"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.63883"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891\u2010021\u201004957\u20104"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.52567\/trj.v6i03.144"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.28008"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000245"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201064059\u20108"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0260106020909047"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S508287"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102019\u2010034455"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2015.04.001"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2012.04.014"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18168666"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2023.107711"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2018.12.008"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010004\u20101014\u20105"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586\u2010015\u20103785\u20105"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31815ce6dd"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hfm.20283"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2010.03.006"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2021.08.008"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891\u2010021\u201004753\u20100"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260614"},{"key":"e_1_2_13_46_2","doi-asserted-by":"crossref","unstructured":"Erratum 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