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Symptoms of pulmonary comorbidities, including pulmonary embolus, pulmonary hypertension, sleep\u2010disordered breathing, and lung malignancy, may be intertwined with symptoms of advancing lung disease. However, the occurrence of extrapulmonary processes, including depression, diabetes mellitus, osteoporosis, and gastroesophageal reflux disease, may be subtle. Clinicians caring for advanced lung disease should be aware of the many comorbid processes that may accompany advancing lung disease.  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