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Extensive clinical research over the last 40 years has improved the techniques to remove the thrombus from the affected limb and reduce the likelihood of developing post\u2010thrombotic syndrome. These treatments have included intravenous systemic thrombolysis, catheter\u2010directed thrombolysis, surgical thrombectomy, and most recently pharmacomechanical thrombectomy to rapidly fragment, lyse, and remove the thrombus from the affected limb. This last technique may finally transform the treatment of acute deep vein thrombus from strictly conservative medical therapy to a minimally invasive procedure that can remove the thrombus to improve the quality of life of millions of individuals suffering from the symptoms of deep vein thrombosis. 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