{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:13:48Z","timestamp":1792088028790,"version":"4.4.0"},"reference-count":92,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,9,12]],"date-time":"2011-09-12T00:00:00Z","timestamp":1315785600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mount Sinai J Medicine"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Allergic rhinitis is a costly disease associated with significant morbidity. It impacts the quality of life of millions of individuals, particularly in industrialized nations, and it is on the rise. Lost productivity and total healthcare expenditure exceeds several billion dollars annually in the United States, with an estimate of &gt;$6 billion spent on prescription medications alone. It is also associated with asthma and other atopic conditions, sinusitis, otitis media, and sleep apnea. Primary care physicians should be well adept at recognizing and initiating empiric first\u2010line therapy for chronic rhinitis. Allergen avoidance, topical nasal steroids, and antihistamines may be sufficient for some patients. In most cases, referral to a board\u2010certified allergy specialist for skin testing and targeted management is indicated. It is essential to make sure that patients abstain from using antihistamines at least 1 week prior to reporting to the allergist for skin testing in order to avoid false\u2010negative results. Traditional subcutaneous allergen immunotherapy, when performed by an experienced allergist, affords relief in &gt;75% of cases. The growing armament of treatment options for refractory allergic rhinitis includes oral and sublingual immunotherapy, recombinant allergens, conjugated DNA vaccines, and anti\u2013immunoglobulin E monoclonal antibody. <jats:bold><jats:italic>Mt Sinai J Med 78:634\u2013644, 2011.<\/jats:italic><\/jats:bold> <jats:italic>\u00a9 2011 Mount Sinai School of Medicine<\/jats:italic><\/jats:p>","DOI":"10.1002\/msj.20287","type":"journal-article","created":{"date-parts":[[2011,9,12]],"date-time":"2011-09-12T23:05:30Z","timestamp":1315868730000},"page":"634-644","source":"Crossref","is-referenced-by-count":13,"title":["Allergic Rhinitis"],"prefix":"10.1002","volume":"78","author":[{"given":"Tania","family":"Mucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Govindaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody","family":"Tversky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,12]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118891"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_8_4_2","first-page":"23","article-title":"Epidemiology of rhinitis: allergic and nonallergic.","volume":"19","author":"Settipane RA","year":"2007","journal-title":"Clin Allergy Immunol"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.06.003"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200403000-00004"},{"issue":"2","key":"e_1_2_8_7_2","first-page":"3","article-title":"Epidemiology of rhinitis and asthma.","volume":"28","author":"Lundback B.","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70463-X"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70296-3"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X112552"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/ai.1994.v94.a54939"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.2.8306032"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-002-0023-0"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)80043-7"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200422060-00002"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-008-0021-y"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-10-54"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62603-8"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)10100-3"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.06.003"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.115569"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000100572"},{"key":"e_1_2_8_23_2","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1542\/peds.94.6.895","article-title":"Epidemiology of physician\u2010diagnosed allergic rhinitis in childhood.","volume":"94","author":"Wright AL","year":"1994","journal-title":"Pediatrics"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2007.28.2953"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6705.953"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)06329-6"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.8.589"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1986.tb01960.x"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/rr179"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01599.x"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03175.x"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-001-0085-4"},{"issue":"4","key":"e_1_2_8_33_2","first-page":"11","article-title":"Genome\u2010wide screen for atopy susceptibility alleles in the Hutterites.","volume":"29","author":"Ober C","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1995.tb00428.x"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00065706"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1524"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1159\/000024096"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01106.x"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.6.9912001"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01737.x"},{"key":"e_1_2_8_41_2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1542\/peds.70.3.437","article-title":"Eosinophilic nonallergic rhinitis in children.","volume":"70","author":"Rupp GH","year":"1982","journal-title":"Pediatrics"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-68-5-975"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.2500\/108854188778965627"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01501.x"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70409-9"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70304-4"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-4-200402170-00010"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200104)31:4<1211::AID-IMMU1211>3.0.CO;2-R"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5844"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1983.tb01592.x"},{"key":"e_1_2_8_51_2","first-page":"630","article-title":"The distribution of dust mite allergen in the houses of patients with asthma.","volume":"124","author":"Tovey ER","year":"1981","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa023171"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1983.tb01591.x"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90132-L"},{"key":"e_1_2_8_55_2","first-page":"25","article-title":"Effectiveness of an acaricide in management of house dust mite allergy.","volume":"67","author":"Brown HM","year":"1991","journal-title":"Ann Allergy"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1991.tb00802.x"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90320-2"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90066-3"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70477-X"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.119155"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90006-7"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.1.9712110"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.6.1334"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00526.x"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.21.2581"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.124467"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80101-0"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70275-1"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70354-9"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200305-640OC"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63545-4"},{"key":"e_1_2_8_72_2","first-page":"128","article-title":"Intranasal steroids and septum perforation\u2014an overlooked complication? A description of the course of events and a discussion of the causes.","volume":"36","author":"Cervin A","year":"1998","journal-title":"Rhinology"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90136-C"},{"key":"e_1_2_8_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02954.x"},{"key":"e_1_2_8_75_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03388.x"},{"key":"e_1_2_8_76_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.9.5724"},{"key":"e_1_2_8_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.09.034"},{"key":"e_1_2_8_78_2","first-page":"148","article-title":"Pharmacoeconomic assessment of specific immunotherapy versus current symptomatic treatment for allergic rhinitis and asthma in France.","volume":"39","author":"Omnes LF","year":"2007","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"e_1_2_8_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.022"},{"key":"e_1_2_8_80_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410702"},{"key":"e_1_2_8_81_2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1542\/peds.42.5.793","article-title":"The value of hyposensitization therapy for bronchial asthma in children\u2014a 14\u2010year study.","volume":"42","author":"Johnstone DE","year":"1968","journal-title":"Pediatrics"},{"key":"e_1_2_8_82_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb01251.x"},{"key":"e_1_2_8_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2009.11.010"},{"key":"e_1_2_8_84_2","doi-asserted-by":"publisher","DOI":"10.2174\/157488607780598340"},{"key":"e_1_2_8_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60474-7"},{"key":"e_1_2_8_86_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02583.x"},{"key":"e_1_2_8_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62171-0"},{"key":"e_1_2_8_88_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00550.x"},{"key":"e_1_2_8_89_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.107927"},{"key":"e_1_2_8_90_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052916"},{"key":"e_1_2_8_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60337-7"},{"key":"e_1_2_8_92_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803725105"},{"key":"e_1_2_8_93_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.056006498.x"}],"container-title":["Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmsj.20287","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/msj.20287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T16:00:25Z","timestamp":1700496025000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/msj.20287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":92,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1002\/msj.20287"],"URL":"https:\/\/doi.org\/10.1002\/msj.20287","archive":["Portico"],"relation":{},"ISSN":["0027-2507","1931-7581"],"issn-type":[{"value":"0027-2507","type":"print"},{"value":"1931-7581","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}