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The reactions are unpredictable and can involve any part of the body, although skin is most frequent. The various pathogenic mechanisms are discussed, along with diagnostic testing, factors predisposing to drug allergy, and reactions to individual drugs and therapeutic reagents. <jats:bold><jats:italic>Mt Sinai J Med 78:717\u2013729, 2011.<\/jats:italic><\/jats:bold> <jats:italic>\u00a9 2011 Mount Sinai School of Medicine<\/jats:italic><\/jats:p>","DOI":"10.1002\/msj.20290","type":"journal-article","created":{"date-parts":[[2011,9,12]],"date-time":"2011-09-12T23:05:30Z","timestamp":1315868730000},"page":"717-729","source":"Crossref","is-referenced-by-count":0,"title":["Immune Reactions to Drugs and Diagnostic Agents"],"prefix":"10.1002","volume":"78","author":[{"given":"Gillian M.","family":"Shepherd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,12]]},"reference":[{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1303"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02742.x"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.08.007"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.07023.x"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198611000-00001"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.198"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:24:3:229"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70343-4"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-5-728"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.028"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.047"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022963"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/08-073"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.111147"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-007-0029-8"},{"key":"e_1_2_13_17_2","unstructured":"JohnsonKK GreenDL RifeJP etal. Sulfonamide cross\u2010reactivity: fact or fiction? [published correction appears inAnn Pharmacother2005;39:1373].Ann Pharmacother2005;39:290\u2013301."},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.035"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000270721.27309.b3"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.02.044"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.022"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.019"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.10.021"}],"container-title":["Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmsj.20290","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/msj.20290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T15:58:18Z","timestamp":1700495898000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/msj.20290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1002\/msj.20290"],"URL":"https:\/\/doi.org\/10.1002\/msj.20290","archive":["Portico"],"relation":{},"ISSN":["0027-2507","1931-7581"],"issn-type":[{"value":"0027-2507","type":"print"},{"value":"1931-7581","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}