{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T07:20:23Z","timestamp":1700551223828},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T00:00:00Z","timestamp":1339027200000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mount Sinai J Medicine"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obesity is a worldwide epidemic leading to severe comorbidity that damages end\u2010organ function. Overall transplant outcomes in this population are inferior to those in nonobese patients. Large population studies show decreased patient and graft survival in obese kidney transplant patients. Despite the poorer outcomes, kidney transplantation is considered because of the survival benefit as compared with the wait\u2010listed dialysis patients. In liver transplantation, the benefit to transplantation as compared with remaining on the list is obvious, as there is no viable liver dialysis at this time. Obesity in potential organ donors impacts both medical and surgical issues. Obesity\u2010related kidney disease affects both the remaining and transplanted kidney. Pancreas donor organs are associated with decreased early graft survival. Liver donor organs with significant steatosis lead to an increased risk for delayed or nonfunction of the organ. Immunosuppressive drugs with variable lipophilicity and altered volume of distribution can greatly affect the therapeutic usefulness of these drugs. Transplant candidates benefit from a multidisciplinary team approach to their care. As the epidemic progresses and less\u2010invasive treatments for metabolic surgery evolve, we are likely to require more patients to lose weight prior to transplantation as we continue to strive for improved outcomes. <jats:italic>Mt Sinai J Med<\/jats:italic> 2012 DOI: 10.1002\/msj.21315<\/jats:p>","DOI":"10.1002\/msj.21315","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T15:39:09Z","timestamp":1339083549000},"page":"388-396","source":"Crossref","is-referenced-by-count":3,"title":["Transplantation in Obese Patient"],"prefix":"10.1002","volume":"79","author":[{"given":"Mary T.","family":"Killackey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,7]]},"reference":[{"key":"e_1_2_10_2_2","volume-title":"World Health Organization. Obesity and overweight factsheet.","year":"2011"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1723"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.23.2847"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.052"},{"key":"e_1_2_10_6_2","unstructured":"World Health Organization.The international classification of adult underweight overweight and obesity according to BMI. Adapted from WHO1995 WHO 2000 and WHO2004."},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.18.2146"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxm007"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr043743"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.2.022305.095249"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910073411501"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020245"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2007.02.002"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000018121.67607.CE"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000118216.84358.22"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/414782a"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.1.30"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200512000-00010"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001496"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.0590041498.x"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.278.5.F817"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000141965.28037.EE"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000141966.69934.21"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00618.x"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e3283414ca1"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2003.50039"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.3.827"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001503-200402000-00005"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.5.445"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2006.10.002"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2005.09.002"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13640-9"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200201150-00013"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2002.01080.x"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00761.x"},{"key":"e_1_2_10_36_2","first-page":"77","article-title":"Survival benefit of kidney and liver transplantation for obese patients on the waiting list.","author":"Pelletier SJ","year":"2003","journal-title":"Clin Transplant"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2004.01.015"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000181094.68259.88"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-011-0356-7"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1177\/011542650702200116"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31819e3f14"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181d2bfb2"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.1999.130111.x"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.02100.x"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00791.x"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00381.x"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2002.32275"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199707270-00012"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200039030-00004"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra011775"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp060033"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2007.00783.x"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08310811"}],"container-title":["Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmsj.21315","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/msj.21315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T06:39:53Z","timestamp":1700548793000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/msj.21315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1002\/msj.21315"],"URL":"https:\/\/doi.org\/10.1002\/msj.21315","archive":["Portico"],"relation":{},"ISSN":["0027-2507","1931-7581"],"issn-type":[{"value":"0027-2507","type":"print"},{"value":"1931-7581","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}