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The presenting symptoms depend on the distribution of nerves affected. One of the most common phenotypes is sensorimotor polyneuropathy, which is characterized by symptoms of neuropathic pain, numbness, and in advanced cases weakness. Symptoms begin in the feet and ultimately progress to the proximal legs and hands. The most common focal neuropathy is a median neuropathy at the wrist, clinically known as carpal tunnel syndrome. Carpal tunnel symptoms may include pain and sensory disturbances in the lateral palm and fingers; hand weakness may ensue if the focal neuropathy is severe. Autonomic neuropathy may affect a variety of organ systems such as the cardiovascular, gastrointestinal, and genitourinary systems. Symptoms may be non\u2010specific making the diagnosis of autonomic neuropathy more difficult to identify. However, it is important to recognize and distinguish autonomic neuropathy from diseases of the end\u2010organs themselves. This article reviews the inherited and acquired amyloidoses that affect the peripheral nervous system including familial amyloid polyneuropathy, and primary, secondary and senile amyloidosis. We emphasize the clinical presentation of the neurologic aspects of these diseases, physical examination findings, appropriate diagnostic evaluation, treatment and prognosis. <jats:bold><jats:italic>Mt Sinai J Med 79:733\u2013748, 2012.<\/jats:italic><\/jats:bold> <jats:italic>\u00a9 2012 Mount Sinai School of Medicine<\/jats:italic><\/jats:p>","DOI":"10.1002\/msj.21352","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T16:16:52Z","timestamp":1355415412000},"page":"733-748","source":"Crossref","is-referenced-by-count":132,"title":["Amyloid Neuropathies"],"prefix":"10.1002","volume":"79","author":[{"given":"Susan 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