{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:26:27Z","timestamp":1759047987199},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,4,23]],"date-time":"2002-04-23T00:00:00Z","timestamp":1019520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several polyneuropathy syndromes have been described with polyclonal serum immunoglobulin G (IgG) or immunoglobulin M (IgM) binding to gangliosides GM2 and GalNAc\u2010GD1a that contain the terminal trisaccharide moiety GalNAc(\u03b21\u20104)Gal(\u03b12\u20103)NeuAc. We describe the clinical and electrodiagnostic features in two patients with serum IgM monoclonal anti\u2010GM2 and anti\u2010GalNAc\u2010GD1a antibodies. These patients had slowly progressive, panmodal sensory loss with severe sensory ataxia. Electrodiagnostic testing showed demyelinating features. Prominent improvement in gait ataxia occurred after treatment with human immune globulin but not after other immunomodulating therapies. Enzyme\u2010linked immunoabsorbent assay and thin\u2010layer chromatography demonstrate that the patient's serum monoclonal IgM bound to gangliosides GM2 and GalNac\u2010GD1a but not to gangliosides without the GalNAc(\u03b21\u20104)Gal(\u03b12\u20103)NeuAc moiety. This neuropathy differs from previously reported neuropathy syndromes associated with polyclonal GM2 and GalNAc\u2010GD1a antibodies and from other chronic demyelinating polyneuropathies. We conclude that a distinct syndrome of chronic demyelinating neuropathy with sensory ataxia, unresponsive to corticosteroids, is associated with monoclonal IgM binding to gangliosides with a terminal GalNAc(\u03b21\u20104)Gal(\u03b12\u20103)NeuAc trisaccharide moiety. Diagnosis of this syndrome is important to direct appropriate treatment. \u00a9 2002 Wiley Periodicals, Inc. Muscle Nerve 25: 000\u2013000, 2002<\/jats:p>","DOI":"10.1002\/mus.10122","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:27:22Z","timestamp":1033907242000},"page":"828-836","source":"Crossref","is-referenced-by-count":32,"title":["Severe sensory ataxia and demyelinating polyneuropathy with IgM anti\u2010GM2 and GalNAc\u2010GD1A antibodies"],"prefix":"10.1002","volume":"25","author":[{"given":"Glenn","family":"Lopate","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rati","family":"Choksi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Pestronk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,5,30]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.9.2122"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00833915"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.8.1577"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310619"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.4.454"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.2.321"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199906)45:6<758::AID-ANA10>3.0.CO;2-N"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410180605"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)68935-5"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(96)00059-8"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.6.641"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.1.116"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(00)00451-3"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200005)23:5<702::AID-MUS6>3.0.CO;2-A"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.5.941"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.6.581"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360313"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.8.677"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916930008994083"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(01)00373-3"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270314"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.5.1289"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.3.357"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.11.2028"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200002)23:2<164::AID-MUS4>3.0.CO;2-Y"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2202"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.7.1304"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(94)90034-5"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.4.951"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.2.204"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.10.1968"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.9.1851"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.10122","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.10122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T05:00:54Z","timestamp":1696914054000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.10122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5,30]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1002\/mus.10122"],"URL":"https:\/\/doi.org\/10.1002\/mus.10122","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5,30]]}}}