{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:48:43Z","timestamp":1790192923758,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,9,18]],"date-time":"2003-09-18T00:00:00Z","timestamp":1063843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relationship between neuropathy and Sj\u00f6gren syndrome has been predicated largely on sicca symptoms or serological abnormalities rather than salivary gland pathology. We reviewed consecutive neuropathy patients who had had a lip biopsy to identify features of the neuropathy that were associated with a positive lip biopsy suggesting Sj\u00f6gren syndrome. Twenty of 54 neuropathy patients were biopsy positive; 13 had a painful or nonspecific sensory neuropathy and only 4 were ataxic. Sicca symptoms were not associated with a positive biopsy (<jats:italic>P<\/jats:italic> = 0.14). Serological abnormalities were found more often in the biopsy\u2010positive group (<jats:italic>P<\/jats:italic> = 0.008), but anti\u2013Sj\u00f6gren syndrome A or B (anti\u2010SSA or SSB) antibodies were detected in only 30%. There were no other clinical or electromyographic (EMG) features associated with a positive biopsy. From this experience, we conclude that: (1) most patients with neuropathy and a positive lip biopsy for Sj\u00f6gren syndrome have a painful, distal, sensory axonal neuropathy; (2) there are no clinical or EMG features that are predictive of a positive lip biopsy; (3) ataxic neuropathy is uncommon; and (4) the lack of sicca symptoms or anti\u2010SSA or SSB antibodies in patients with neuropathy does not exclude Sj\u00f6gren syndrome based upon salivary gland pathology. Muscle Nerve 28: 553\u2013560, 2003<\/jats:p>","DOI":"10.1002\/mus.10470","type":"journal-article","created":{"date-parts":[[2003,10,17]],"date-time":"2003-10-17T12:04:08Z","timestamp":1066392248000},"page":"553-560","source":"Crossref","is-referenced-by-count":52,"title":["Positive salivary gland biopsy, Sj\u00f6gren syndrome, and neuropathy: Clinical implications"],"prefix":"10.1002","volume":"28","author":[{"given":"Kenneth C.","family":"Gorson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan H.","family":"Ropper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,10,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880120602"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.5.1451"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000052142"},{"key":"e_1_2_7_5_2","first-page":"29","volume-title":"Diagnosis and management of peripheral nerve disorders","author":"Cornblath DR","year":"2001"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1212\/WNL.41.5.617","article-title":"Research criteria for the diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP)","volume":"41","author":"Cornblath DR","year":"1991","journal-title":"Neurology"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400516"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009749509100886"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.6.799"},{"key":"e_1_2_7_10_2","first-page":"931","volume-title":"Textbook of rheumatology","author":"Fox RI","year":"1993"},{"key":"e_1_2_7_11_2","first-page":"1027","volume-title":"Textbook of rheumatology","author":"Fox RI","year":"2001"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1995.tb00150.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.1069"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.4.855"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270313"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880130703"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199903)22:3<404::AID-MUS15>3.0.CO;2-E"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.3.615"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880060706"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880120402"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150170135"},{"key":"e_1_2_7_22_2","first-page":"247","article-title":"Establishing guidelines for the role of minor salivary gland biopsy in clinical practice for Sj\u00f6gren's syndrome","volume":"25","author":"Lee M","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.10.1276"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880170908"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.3.390"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.1.151"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200001)23:1<73::AID-MUS9>3.0.CO;2-5"},{"issue":"8","key":"e_1_2_7_28_2","first-page":"225","article-title":"Consensus criteria for the diagnosis of partial conduction block","volume":"22","author":"Olney RK","year":"1999","journal-title":"Muscle Nerve"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.2.650-b"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)62408-7"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00131402-200103000-00007"},{"key":"e_1_2_7_32_2","first-page":"766","article-title":"The frequency of sicca syndrome in an elderly female population","volume":"14","author":"Strickland RW","year":"1987","journal-title":"J Rheumatol"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine1962.27.2"},{"key":"e_1_2_7_34_2","first-page":"247","article-title":"Monoclonal immunoglobulins in the serum of patients with primary Sj\u00f6gren's syndrome","volume":"6","author":"Youinou P","year":"1988","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.63.3.376"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.5.575"},{"key":"e_1_2_7_37_2","first-page":"1515","article-title":"Minor salivary gland biopsies in patients investigated for primary Sj\u00f6gren syndrome. A review of 187 patients","volume":"20","author":"Wise C","year":"1993","journal-title":"J Rheumatol"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.10470","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.10470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T19:44:22Z","timestamp":1696707862000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.10470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,16]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["10.1002\/mus.10470"],"URL":"https:\/\/doi.org\/10.1002\/mus.10470","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,16]]}}}