{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:51:33Z","timestamp":1761742293579,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,1,2]],"date-time":"2004-01-02T00:00:00Z","timestamp":1073001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["02-0005"],"award-info":[{"award-number":["02-0005"]}]},{"DOI":"10.13039\/501100006280","name":"Ministerio de Ciencia y Tecnolog\u00eda","doi-asserted-by":"crossref","award":["SAF2001-4681-E"],"award-info":[{"award-number":["SAF2001-4681-E"]}],"id":[{"id":"10.13039\/501100006280","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Centro de Investigaci\u00f3n de Enfermedades Neurol\u00f3gicas network project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oxidative stress has been implicated in the pathogenesis of several muscle diseases. Semicarbazide\u2010sensitive amine oxidase (SSAO) metabolizes oxidative deamination of primary aromatic and aliphatic amines. In the oxidative reactions, amine substrates are converted into the aldehyde, followed by the production of ammonia and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. Although normal levels in muscle are very low, SSAO is expressed in almost all mammalian tissues. In this study, we examined the possible implication of SSAO as an additional source of oxidative stress in the pathogenesis of muscle disorders. The expression of SSAO was examined immunohistochemically in muscle biopsy specimens from patients with inclusion\u2010body myositis (IBM; <jats:italic>n<\/jats:italic> = 5), desmin\u2010related myopathy (DRM; <jats:italic>n<\/jats:italic> = 3), dermatomyositis (<jats:italic>n<\/jats:italic> = 3), granulomatous (sarcoid) myopathy (<jats:italic>n<\/jats:italic> = 2), muscle denervation\u2013reinnervation (<jats:italic>n<\/jats:italic> = 3), and rhabdomyolysis (<jats:italic>n<\/jats:italic> = 2), as well as from control subjects (<jats:italic>n<\/jats:italic> = 3). Strong SSAO immunoreactivity was present in vacuolated and nonvacuolated fibers in IBM, in abnormal fibers in DRM, and in degenerating and regenerating fibers in dermatomyositis and rhabdomyolysis. In addition, SSAO overexpression was observed in muscle fibers adjacent to granulomas in sarcoid myopathy. These results suggest that SSAO is a source of oxidative stress in diseased human skeletal muscle and that it contributes to oxidative stress\u2010induced damage in various inflammatory and other myopathies. Alternatively, the expression of SSAO in muscle fibers may be a consequence of muscle fiber injury. Muscle Nerve 29: 261\u2013266, 2004<\/jats:p>","DOI":"10.1002\/mus.10550","type":"journal-article","created":{"date-parts":[[2004,1,28]],"date-time":"2004-01-28T11:00:34Z","timestamp":1075287634000},"page":"261-266","source":"Crossref","is-referenced-by-count":10,"title":["Overexpression of semicarbazide\u2010sensitive amine oxidase in human myopathies"],"prefix":"10.1002","volume":"29","author":[{"given":"Montse","family":"Oliv\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merc\u00e8","family":"Unzeta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isidro","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,1,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215540104900208"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/60.1.1"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200210000-00002"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.7.915"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.5.C1424"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-199510000-00009"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003163421104"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199605000-00009"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/hq0102.101550"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.14.8025"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.9.4820"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199612200-00070"},{"key":"e_1_2_7_14_2","first-page":"223","article-title":"Mammalian monoamine\u2010oxidizing enzymes with special reference to benzylaamine oxidase in human tissues","volume":"17","author":"Lewishon R","year":"1984","journal-title":"Braz J Med Biol Res"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/1357-2725(95)00130-1"},{"key":"e_1_2_7_16_2","first-page":"415","article-title":"Several aspects of the amine oxidation by semi\u2010carbazide\u2010sensitive amine oxidase (SSAO) from bovine lung","volume":"41","author":"Lizcano JM","year":"1994","journal-title":"J Neural Transm"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3310069"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.5.1024"},{"key":"e_1_2_7_19_2","first-page":"563","article-title":"Semicarbazide\u2010sensitive amine oxidase substrates stimulate glucose transport and inhibit lipolysis in human adipocytes","volume":"297","author":"Morin N","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199605000-00008"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1172"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2001.00824.x"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.2003.00428.x"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.1.17"},{"key":"e_1_2_7_25_2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00401-003-0685-2","article-title":"Oxidative stress and predominant A\u03b242(43) deposition in myopathies with rimmed vacuoles","volume":"105","author":"Tateyama M","year":"2003","journal-title":"Acta Neuropathol"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1998.4527"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010100428"},{"key":"e_1_2_7_28_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/448","article-title":"Radicals r'aging","volume":"19","author":"Wallace DC","year":"1998","journal-title":"Nat Genet"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.6.1089"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6499-0_19"},{"key":"e_1_2_7_31_2","doi-asserted-by":"crossref","first-page":"594","DOI":"10.2337\/diab.42.4.594","article-title":"Oxidative deamination of methylamine by SSAO leads to cyotoxic damage in endothelial cells, possible consequences for diabetes","volume":"42","author":"Yu PH","year":"1993","journal-title":"Diabetes"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-9639(03)00039-6"}],"container-title":["Muscle &amp; 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