{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:54:21Z","timestamp":1781520861146,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,5,15]],"date-time":"2001-05-15T00:00:00Z","timestamp":989884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mRNA levels of nerve growth factor (NGF), glial cell line\u2013derived neurotrophic factor (GDNF), ciliary neurotrophic factor (CNTF), and interleukin\u20106 (IL\u20106) were examined in sural nerves of 22 patients with acute necrotizing vasculitic neuropathies. NGF, GDNF, and IL\u20106 mRNAs were upregulated and CNTF mRNA was downregulated in the lesioned nerves, but their up\u2010 and down\u2010regulation levels were not correlated with each other, showing that these mRNAs were independently expressed. The expression of NGF and CNTF mRNAs was clearly correlated with the degree of infiltrated macrophages and T cells, and myelinated fiber density, respectively. These findings indicate that these neurotrophic factors are differentially expressed temporally and spatially in the vasculitic nerve lesion by an underlying pathology\u2010related process. \u00a9 2001 John Wiley &amp; Sons, Inc. Muscle Nerve 24: 830\u2013833, 2001<\/jats:p>","DOI":"10.1002\/mus.1077","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T22:08:54Z","timestamp":1030313334000},"page":"830-833","source":"Crossref","is-referenced-by-count":17,"title":["Pathology\u2010related differential expression regulation of NGF, GDNF, CNTF, and IL\u20106 mRNAs in human vasculitic neuropathy"],"prefix":"10.1002","volume":"24","author":[{"given":"Masahiko","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norimasa","family":"Mitsuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Sobue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,5,15]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90168-D"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.3.427"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.5.2175"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8735"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00242-X"},{"key":"e_1_2_7_7_2","unstructured":"ItoY YamamotoM LiM MitsumaN HattoriN SobueG.Expression of mRNAs for ciliary neurotrophic factor (CNTF) leukemia inhibitory factor (LIF) interleukin\u20106 (IL\u20106) and their receptors (CNTFR\u03b1 LIFR\u03b2 IL\u20106R\u03b1 and gp130) in human peripheral neuropathies. Neurochem Res (in press)."},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.3.469"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990125)403:4<471::AID-CNE4>3.0.CO;2-S"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80966-6"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80039-2"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022434209787"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240112"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.130.1.137"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00858-0"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.1077","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.1077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T19:11:02Z","timestamp":1696792262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.1077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5,15]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1002\/mus.1077"],"URL":"https:\/\/doi.org\/10.1002\/mus.1077","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5,15]]}}}