{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:04:20Z","timestamp":1760187860690},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2001,9,13]],"date-time":"2001-09-13T00:00:00Z","timestamp":1000339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polyneuropathy associated with monoclonal gammopathy of undetermined significance (MGUS) is a well\u2010known disease entity. Of the patients with monoclonal gammopathy without neuropathy, 25% develop a hematological malignancy during long\u2010term follow\u2010up. Whether the frequency of hematological malignancy is similar in patients with polyneuropathy associated with monoclonal gammopathy and whether hematological screening is necessary in these patients is unknown. To determine the frequency of and risk factors for a hematological malignancy, we investigated 104 patients with polyneuropathy and monoclonal gammopathy. Potential diagnostic variables were obtained from medical history, physical and neurological examination, and laboratory analysis. The associations between potential diagnostic variables and outcome, hematological malignancy, were evaluated by univariable and multivariable logistic\u2010regression analysis. Among our patients, 23 had a hematological malignancy (8 multiple myeloma, 10 low\u2010grade lymphoma, 3 plasmacytoma, 1 Castleman's disease and 1 POEMS syndrome [polyneuropathy, organomegaly, endocrinopathy, M\u2010protein, and skin changes]). Weight loss, progression of the neuropathy, and an M\u2010protein level &gt; 1 g\/L were independent risk factors for malignancy. Extensive screening is indicated in patients with these features. \u00a9 2001 John Wiley &amp; Sons, Inc. Muscle Nerve 24: 1295\u20131302, 2001<\/jats:p>","DOI":"10.1002\/mus.1147","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:23:24Z","timestamp":1030310604000},"page":"1295-1302","source":"Crossref","is-referenced-by-count":23,"title":["Risk factors for hematological malignancy in polyneuropathy associated with monoclonal gammopathy"],"prefix":"10.1002","volume":"24","author":[{"given":"Marijke","family":"Eurelings","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolette C.","family":"Notermans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels W.C.J.","family":"Van de Donk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk M.","family":"Lokhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,9,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2003.00687.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1966.tb05453.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1182\/blood.V87.3.912.bloodjournal873912","article-title":"Role of diffrent hematologic variables in defining the risk of malignant transformation in monoclonal gammopathy","volume":"87","author":"Baldini L","year":"1996","journal-title":"Blood"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb08245.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1101(1999)14:3<149::AID-JCA8>3.0.CO;2-9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.63.2.163"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300111"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.12.3835"},{"key":"e_1_2_6_11_2","first-page":"140","volume-title":"Applied logistic regression","author":"Hosmer DW","year":"1989"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520360073015"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880060706"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(95)00021-6"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90522-3"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70416-0"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30205-6"},{"key":"e_1_2_6_18_2","first-page":"1294","volume-title":"Peripheral neuropathy","author":"Kyle RA","year":"1993"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(88)80008-8"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.497"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370705"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.308.6935.1033"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690395"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.5.1227"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050124"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.10.1066"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.6.1385"},{"key":"e_1_2_6_28_2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/brain\/119.2.421","article-title":"Chronic idiopathic axonal polyneuropathy. Comparison of patients with and without monoclonal gammopathy","volume":"119","author":"Notermans NC","year":"1996","journal-title":"Brain"},{"key":"e_1_2_6_29_2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3109\/10428199709058316","article-title":"Development of a \u201cMyeloma Risk Score\u201d using a population based registry of paraproteinemia and myeloma","volume":"27","author":"Ong FR","year":"1997","journal-title":"Leuk Lymphoma"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.3.357"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200002)23:2<164::AID-MUS4>3.0.CO;2-Y"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199907)22:7<800::AID-MUS2>3.0.CO;2-F"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(91)90020-E"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805283382207"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.47.8.813"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.5.1233"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199605)19:5<637::AID-MUS12>3.0.CO;2-K"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05256.x"},{"key":"e_1_2_6_39_2","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/01.STR.19.5.604","article-title":"Interobserver agreement for assessment of handicap in stroke patients","volume":"19","author":"Van Swieten JC","year":"1988","journal-title":"Stroke"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.1072923.x"},{"key":"e_1_2_6_41_2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/BF00319857","article-title":"The clinical spectrum of peripheral neuropathies associated with benign monoclonal IgM, IgG and IgA paraproteinaemia. Comparative clinical, immunological and nerve biopsy findings","volume":"238","author":"Yeung KB","year":"1991","journal-title":"J Neurol"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.1147","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.1147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T12:53:53Z","timestamp":1700398433000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.1147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9,13]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["10.1002\/mus.1147"],"URL":"https:\/\/doi.org\/10.1002\/mus.1147","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9,13]]}}}