{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:17:33Z","timestamp":1775060253586,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,7,28]],"date-time":"2004-07-28T00:00:00Z","timestamp":1090972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The \u03b3\u03b4 T cells participate in microbial defense, are prevalent in intestinal epithelia, and are activated in autoimmune diseases. We studied whether peripheral blood \u03b3\u03b4 cells and \u03b3\u03b4 subsets are increased in Guillain\u2013Barr\u00e9 syndrome (GBS) and whether elevations are associated with <jats:italic>Campylobacter jejuni<\/jats:italic> infection or GM1 elevations. In 20 GBS patients, we performed serial flow cytometry studies of blood \u03b3\u03b4, V\u03b41, and V\u03b42 cells (\u00b1CD8<jats:sup>+<\/jats:sup>), <jats:italic>C jejuni<\/jats:italic>, and ganglioside titers. There was no significant difference in median \u03b3\u03b4 T\u2010cell percentages between GBS patients and controls at onset and at convalescence. However, 5 patients had marked V\u03b41\/CD8<jats:sup>+<\/jats:sup> elevations. Elevated V\u03b41 or V\u03b41\/CD8<jats:sup>+<\/jats:sup> cells occurred in 3 of 6 patients with <jats:italic>C jejuni<\/jats:italic> or GM1 titer elevations. A minority of GBS patients have elevations of V\u03b41\/CD8<jats:sup>+<\/jats:sup> cells, possibly associated with elevated <jats:italic>C jejuni<\/jats:italic> or GM1 titers. The \u03b3\u03b4 T cells may have a cytotoxic (or suppressor) role in the disease. Muscle Nerve 30: 423\u2013432, 2004<\/jats:p>","DOI":"10.1002\/mus.20105","type":"journal-article","created":{"date-parts":[[2004,7,28]],"date-time":"2004-07-28T23:00:27Z","timestamp":1091055627000},"page":"423-432","source":"Crossref","is-referenced-by-count":11,"title":["Blood \u03b3\u03b4 T cells, <i>Campylobacter jejuni<\/i>, and GM1 titers in Guillain\u2013Barr\u00e9 syndrome"],"prefix":"10.1002","volume":"30","author":[{"given":"Stephen N.","family":"Scelsa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violette","family":"Ghali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Herskovitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyllis","family":"Bieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah L.","family":"Shank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel D. 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