{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:06:18Z","timestamp":1790517978287,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,5]],"date-time":"2004-10-05T00:00:00Z","timestamp":1096934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have studied a large Swedish family with a mutation in the nerve growth factor beta (<jats:italic>NGFB<\/jats:italic>) gene causing insensitivity to deep pain without anhidrosis (hereditary sensory and autonomic neuropathy, type V; HSAN V). Painfree joint destruction and fractures were common. Peripheral nerve conduction was normal, but temperature thresholds were increased. Sural nerve biopsies showed a moderate loss of A\u03b4 fibers and a severe reduction of C fibers. The three most severely affected cases were all born to consanguineous parents, and were homozygotes for the causal genetic mutation. Treatment of these patients is discussed. Muscle Nerve, 2004<\/jats:p>","DOI":"10.1002\/mus.20172","type":"journal-article","created":{"date-parts":[[2004,10,6]],"date-time":"2004-10-06T07:01:04Z","timestamp":1097046064000},"page":"752-760","source":"Crossref","is-referenced-by-count":78,"title":["Familial insensitivity to pain (HSAN V) and a mutation in the <i>NGFB<\/i> gene. A neurophysiological and pathological study"],"prefix":"10.1002","volume":"30","author":[{"given":"Jan","family":"Minde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Toolanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Nennesmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingela Nilsson","family":"Remahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olle","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Solders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,5]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/318808"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1984.02140480049016"},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.2106\/00004623-200011000-00008","article-title":"Orthopaedic manifestations of familial dysautonomia","volume":"11","author":"Bar\u2010On E","year":"2000","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216450"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(89)90075-0"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/85879"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh096"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.39.11.1071"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.9.793"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s102860200017"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200X.2002.01571.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150810"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s102860200016"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(85)90120-0"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90286-L"},{"key":"e_1_2_7_17_2","first-page":"249","article-title":"Pain terms: a list with definitions and notes on usage. Recommended by the IASP Subcommitte on Taxonomy","volume":"6","author":"Merskey H","year":"1979","journal-title":"Pain"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00482-7"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/323252"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00351-5"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1983.tb04577.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-7488"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(94)90091-4"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(01)00347-2"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/318810"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/368246a0"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10245"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007760170010"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.126"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1962.01590030023004"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.20172","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.20172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T16:13:13Z","timestamp":1700237593000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.20172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,5]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1002\/mus.20172"],"URL":"https:\/\/doi.org\/10.1002\/mus.20172","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,5]]}}}