{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:49:22Z","timestamp":1762541362808},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pathophysiology of neuropathic pain in Fabry's disease (FD) is still largely unknown. Seven FD patients were studied by laser evoked potentials (LEPs) to assess the function of the A\u03b4 and C fibers. Laser pulses were delivered on the skin of the hand and perioral region at painful intensity to record LEPs related to A\u03b4\u2010fiber inputs and at nonpainful intensity to obtain LEPs related to C\u2010fiber inputs. When the perioral region was stimulated, a vertex positive component was recorded with a mean latency of 260.3 ms and 376 ms after A\u03b4\u2010 and C\u2010fiber stimulation, respectively. The mean A\u03b4\u2010LEP amplitude was significantly lower in FD patients (N1\/P1 mean values were 2.8 \u03bcV and 4.5 \u03bcV after hand and face stimulation, respectively, compared to 4 \u03bcV and 8.9 \u03bcV for controls; N2\/P2 mean values were 8.2 \u03bcV and 11.1 \u03bcV after hand and face stimulation, respectively, and 16.7 \u03bcV and 22.3 \u03bcV in controls). Unlike the healthy subjects, 6 FD patients, suffering from neuropathic pain, showed a late positive potential related to C\u2010fiber function (mean latency, 377.1 ms) also after facial stimulation at painful intensity, suggesting a relative overflow of C\u2010fiber input, which may be relevant in the pathophysiology of pain in this disease. Muscle Nerve, 2004<\/jats:p>","DOI":"10.1002\/mus.20174","type":"journal-article","created":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T22:01:52Z","timestamp":1096668112000},"page":"708-713","source":"Crossref","is-referenced-by-count":35,"title":["Functional assessment of A\u03b4 and C fibers in patients with Fabry's disease"],"prefix":"10.1002","volume":"30","author":[{"given":"Massimiliano","family":"Valeriani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Mariotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenica","family":"Le Pera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Restuccia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liala","family":"De Armas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toni","family":"Maiese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Vigevano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Antuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Zampino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Tonali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1651-2227.2002.tb03107.x","article-title":"Mechanisms of neuropathic pain and their importance in Fabry disease","volume":"91","author":"Birklein F","year":"2002","journal-title":"Acta Paediatr"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00663913"},{"key":"e_1_2_6_4_2","first-page":"625","article-title":"Laser\u2010evoked cerebral potentials in the assessment of cutaneous pain sensitivity in normal subjects and patients","volume":"147","author":"Bromm B","year":"1991","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_6_5_2","first-page":"33","article-title":"Nerve fibres discharges cerebral potentials and sensations induced by CO2 laser stimulation","volume":"3","author":"Bromm B","year":"1984","journal-title":"Human Neurobiol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg227"},{"key":"e_1_2_6_7_2","first-page":"157","article-title":"Fabry's disease: enzymatic diagnosis of hemizygotes and heterozygotes. 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