{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:17:44Z","timestamp":1791051464025,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,11,9]],"date-time":"2004-11-09T00:00:00Z","timestamp":1099958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myotonic dystrophy (DM1) is an autosomal\u2010dominant multisystem disease characterized by progressive skeletal muscle weakness, myotonia, cataracts, cardiac arrhythmias, mild mental retardation, and endocrinopathies. Heterozygous loss of <jats:italic>SIX5<\/jats:italic> in mice causes cataracts and cardiac conduction disease, and homozygous loss also leads to sterility and decreased testicular mass, reminiscent of DM1 in humans. The effect of <jats:italic>SIX5<\/jats:italic> deficiency in muscle is unknown. In this study, we found that muscle contractile properties, electromyographic insertional activity, and muscle histology were normal in <jats:italic>SIX5<\/jats:italic> deficient mice. The implications of these findings for the pathogenesis of DM1 are discussed. Muscle Nerve, 2004<\/jats:p>","DOI":"10.1002\/mus.20239","type":"journal-article","created":{"date-parts":[[2004,11,10]],"date-time":"2004-11-10T08:51:45Z","timestamp":1100076705000},"page":"503-505","source":"Crossref","is-referenced-by-count":19,"title":["Myotonia and muscle contractile properties in mice with <i>SIX5<\/i> deficiency"],"prefix":"10.1002","volume":"31","author":[{"given":"Kirkwood E.","family":"Personius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyti","family":"Nautiyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sita","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900804"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.8.1491"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5346"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.10.1919"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90154-5"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2001.3229"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1546326"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8469976"},{"key":"e_1_2_7_10_2","series-title":"Myotonic dystrophy","first-page":"384","author":"Harper PS","year":"1989"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088583"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0897-402"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/75490"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1546325"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5485.1769"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.hmg.a018923"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.12.5465"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80480-8"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0796-325"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/75500"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh161"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.23.2717"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.128.6.995"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0897-407"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020881520353"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.3.481"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.20239","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.20239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:11:11Z","timestamp":1700179871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.20239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,9]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1002\/mus.20239"],"URL":"https:\/\/doi.org\/10.1002\/mus.20239","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,9]]}}}