{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T07:01:10Z","timestamp":1769929270866,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,12,21]],"date-time":"2004-12-21T00:00:00Z","timestamp":1103587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Association Fran\u00e7aise contre les Myopathies (AFM)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>McArdle's disease is a common disorder of muscle metabolism and is due to myophosphorylase deficiency. The major complaint of patients with this disease is effort intolerance. Although the clinical features of affected patients are well known, their daily lifestyle is not well documented. The main objective of this work was to assess their mean daily energy expenditure (DEE) and compare it with control subjects. Thirty patients and 87 control subjects completed a questionnaire. A 3\u2010day self\u2010record of daily physical activities was used to estimate the mean DEE for patients and control subjects. A separate section of the questionnaire was used to assess patients' clinical features and daily lifestyle. The DEE of patients (44.1 \u00b1 6.9 kcal\/kg) was not significantly different from control subjects (44.5 \u00b1 5.6 kcal\/kg). Half of the patients with McArdle's disease performed a daily physical leisure activity as sport, sometimes at a high level (17%). Despite large individual variation, physical abilities and patients' symptoms were negatively correlated. Physical leisure activity significantly decreased the sensation of muscle pain (<jats:italic>P<\/jats:italic>&lt; 0.03). These findings show that patients with McArdle's disease do not have a strictly sedentary lifestyle. Moreover, physical exercise appears to have positive effects on the main clinical features, such as effort intolerance. Thus, regular, moderate physical activity may be beneficial in McArdle's disease. Muscle Nerve, 2005<\/jats:p>","DOI":"10.1002\/mus.20251","type":"journal-article","created":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T00:18:12Z","timestamp":1103674692000},"page":"637-641","source":"Crossref","is-referenced-by-count":39,"title":["Exercise tolerance and daily life in McArdle's disease"],"prefix":"10.1002","volume":"31","author":[{"given":"Karen","family":"Ollivier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Yves","family":"Hogrel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Gomez\u2010Merino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma B.","family":"Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Lafor\u00eat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Eymard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Portero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(95)00060-H"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/37.3.461"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/109.6.1087"},{"key":"e_1_2_7_5_2","first-page":"457","article-title":"Exercise intolerance in patients with McArdle's disease or mitochondrial myopathies","volume":"1","author":"Chaussain M","year":"1992","journal-title":"Eur J Med"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1992.262.2.E167"},{"key":"e_1_2_7_7_2","volume-title":"Physiological measurements of metabolic functions in man","author":"Consolazio CF","year":"1963"},{"key":"e_1_2_7_8_2","first-page":"1585","volume-title":"Myology","author":"DiMauro S","year":"1986"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524024605770"},{"key":"e_1_2_7_10_2","volume-title":"Energy, work and leisure","author":"Durnin JVGA","year":"1967"},{"key":"e_1_2_7_11_2","first-page":"A369","article-title":"Aerobic conditioning: an effective therapy in McArdle's disease","volume":"50","author":"Haller RG","year":"1998","journal-title":"Neurology"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.7.923"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.9.1395"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.12.1733"},{"key":"e_1_2_7_15_2","first-page":"67","article-title":"Skeletal muscle disorders and associated factors that limit exercise performance","volume":"17","author":"Lewis SF","year":"1989","journal-title":"Exerc Sport Sci Rev"},{"key":"e_1_2_7_16_2","first-page":"13","article-title":"Myopathy due to a defect in muscle glycogen breakdown","volume":"10","author":"McArdle B","year":"1951","journal-title":"Clin Sci"},{"key":"e_1_2_7_17_2","first-page":"107","article-title":"Diagnosis and therapy of myophosphorylase deficiency: experience with a group of Italian patients","volume":"6","author":"Martinuzzi A","year":"1996","journal-title":"Basic Appl Myol"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1955.35.4.801"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018260"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(61)90075-4"},{"key":"e_1_2_7_21_2","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.0954-6820.1967.tb12635.x","article-title":"The second wind phenomenon in McArdle's syndrome","volume":"472","author":"Pernow BB","year":"1967","journal-title":"Acta Med Scand"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-199622010-00001"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199911001-00007"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-2-8178-0855-0_1"}],"container-title":["Muscle &amp; 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