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We studied the distribution of \u03b2\u2010chemokine receptors in polymyositis (PM), sporadic inclusion\u2010body myositis (sIBM), dermatomyositis (DM), and control samples. CCR1\u20135 were localized to blood vessels in all samples. In addition, increased endothelial expression of CCR2A was observed in IIM. Subsets of inflammatory cells, identified as macrophages and T cells, in all three types of IIM expressed CCR2A, CCR2B, CCR3, CCR4, and CCR5. In contrast to an earlier report, we found CCR2B to be the most prominent MCP\u20101 receptor on inflammatory cells in IIM, especially in PM and sIBM. Strong CCR4 expression was present on myonuclei of regenerating muscle fibers. The prominence of the CCR2 receptors further underlines the importance of the interaction with their ligand MCP\u20101 in the immunopathogenesis of IIM and puts CCR2B forward as a potential target for future therapeutic intervention. 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