{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:06:22Z","timestamp":1791558382860,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with mitochondrial myopathies (MM) usually suffer from exercise intolerance due to their impaired oxidative capacity and physical deconditioning. We evaluated the effects of a 12\u2010week supervised randomized rehabilitation program involving endurance training in patients with MM. Twenty MM patients were assigned to a training or control group. For three nonconsecutive days each week, patients combined cycle exercise at 70% of their peak work rate with three upper\u2010body weight\u2010lifting exercises performed at 50% of maximum capacity. Training increased maximal oxygen uptake (28.5%), work output (15.5%), and minute ventilation (40%), endurance performance (62%), walking distance in shuttle walking test (+95 m), and peripheral muscle strength (32%\u201362%), and improved Nottingham Health Profile scores (21.47%) and clinical symptoms. Control MM patients did not change from baseline. Results show that our exercise program is an adequate training strategy for patients with mitochondrial myopathy. Muscle Nerve, 2005<\/jats:p>","DOI":"10.1002\/mus.20368","type":"journal-article","created":{"date-parts":[[2005,6,17]],"date-time":"2005-06-17T00:16:43Z","timestamp":1118967403000},"page":"342-350","source":"Crossref","is-referenced-by-count":87,"title":["Exercise training in mitochondrial myopathy: A randomized controlled trial"],"prefix":"10.1002","volume":"32","author":[{"given":"Pilar","family":"Cejudo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Bautista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodoro","family":"Montemayor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Villag\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hildegard","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Arenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.80.6.704"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000033795.17156.00"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1152\/jappl.1990.69.5.1725","article-title":"Positive adaptations to weightlifting training in the elderly","volume":"69","author":"Brown AB","year":"1990","journal-title":"J Appl Physiol"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0272-5231(21)01069-8","article-title":"Physiologic responses to training","volume":"15","author":"Casaburi R","year":"1994","journal-title":"Clin Chest Med"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(03)00097-X"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.2.634"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.1.182"},{"key":"e_1_2_7_10_2","first-page":"263","article-title":"Techniques of progressive resistance exercise","volume":"2","author":"DeLorme TL","year":"1948","journal-title":"Arch Phys Med"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30332-3"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.1.106"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7753(00)71216-4"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.3.2005110"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/00913847.1988.11709461"},{"key":"e_1_2_7_16_2","first-page":"454","article-title":"Respiratory function tests: normal values at median altitudes and the prediction of normal results","volume":"79","author":"Goldman HI","year":"1959","journal-title":"Am Rev Tuberc"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.15.11.1701"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/331717a0"},{"key":"e_1_2_7_19_2","first-page":"185","article-title":"Measuring health status: a new tool for clinicians and epidemiologists","volume":"35","author":"Hunt SM","year":"1985","journal-title":"J R Coll Gen Pract"},{"key":"e_1_2_7_20_2","first-page":"526","volume-title":"Rehabilitation medicine. Principles and practice","author":"Joynt RL","year":"1993"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30170-5"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198808000-00006"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2107081"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/109.5.915"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1519\/1533-4287(2001)015<0519:OAFTST>2.0.CO;2"},{"key":"e_1_2_7_26_2","first-page":"371","volume-title":"Exercise in health and disease","author":"Pollock ML","year":"1990"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(95)00064-X"},{"key":"e_1_2_7_28_2","first-page":"7","article-title":"Standardized lung function testing","volume":"19","author":"Quanjer PH","year":"1983","journal-title":"Bull Eur Physiopathol Respir"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(01)00314-5"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(99)00068-1"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.12.1019"},{"issue":"38","key":"e_1_2_7_32_2","first-page":"67S","article-title":"What is the minimum clinically important difference in the incremental shuttle walking test (ISWT) observed in pulmonary rehabilitation?","volume":"20","author":"Singh SJ","year":"2002","journal-title":"Eur Respir J"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.2.529"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.4.1055"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199909)22:9<1239::AID-MUS11>3.0.CO;2-W"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70177-8"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1050"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5407.1482"},{"key":"e_1_2_7_39_2","first-page":"274","volume-title":"Principles of exercise testing and interpretation","author":"Wasserman K","year":"1987"},{"key":"e_1_2_7_40_2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0272-5231(21)01068-6","article-title":"Behind the scenes of cardiopulmonary exercise testing","volume":"15","author":"Zeballos RJ","year":"1994","journal-title":"Clin Chest Med"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.20368","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.20368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T06:39:49Z","timestamp":1696919989000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.20368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,16]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1002\/mus.20368"],"URL":"https:\/\/doi.org\/10.1002\/mus.20368","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,16]]}}}