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We report the clinical and pathological findings of a 36\u2010year\u2010old patient with fulminant quadriplegic neuropathy, left facial nerve palsy, and Burkitt\u2010like lymphoma. Features of the neuropathy, which occurred during induction chemotherapy with a total cumulative dose of 4 mg vincristine, suggested axonal Guillain\u2013Barr\u00e9 syndrome. There was no evidence of direct malignant infiltration of the peripheral nervous system. We hypothesize that immune mechanisms triggered by the lymphoma initiated damage to the peripheral nervous system and enhanced its vulnerability to the toxic effects of vincristine. 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