{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:07:27Z","timestamp":1780459647089,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,8,23]],"date-time":"2006-08-23T00:00:00Z","timestamp":1156291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Copper deficiency in humans is a rare cause of myeloneuropathy that usually presents with a spastic ataxic gait, hyperreflexia, and distal sensory loss similar to that seen in patients with subacute combined degeneration. We describe three copper\u2010deficient patients, two of whom were referred with a presumptive diagnosis of amyotrophic lateral sclerosis, who had progressive asymmetric weakness or electrodiagnostic findings of proximal and distal denervation suggestive of lower motor neuron disease. Copper replacement resulted in stabilization or mild improvement in weakness. The clinical spectrum of human copper deficiency should include lower motor neuron disease in addition to a syndrome of spastic ataxia. Muscle Nerve, 2006<\/jats:p>","DOI":"10.1002\/mus.20631","type":"journal-article","created":{"date-parts":[[2006,8,23]],"date-time":"2006-08-23T21:55:48Z","timestamp":1156370148000},"page":"789-793","source":"Crossref","is-referenced-by-count":70,"title":["Motor neuron disease associated with copper deficiency"],"prefix":"10.1002","volume":"34","author":[{"given":"Conrad C.","family":"Weihl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Lopate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,23]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1093\/ajcn\/34.9.1670","article-title":"The effect of dietary zinc on intestinal copper absorption","volume":"34","author":"Fischer PW","year":"1981","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0263-0"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0256"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(92)90162-6"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.9.1303"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.1999.01095.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.12.1782"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000132644.52613.FA"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.4065\/80.7.943"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4859-1_8"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02962153"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000032497.30439.F6"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207356200"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.046987"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150170118"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.4065\/81.1.104"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(83)90192-2"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1309\/V6GVYW2QTYD5C5PJ"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1986.9694017"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.20631","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.20631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T17:56:20Z","timestamp":1696874180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.20631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,23]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1002\/mus.20631"],"URL":"https:\/\/doi.org\/10.1002\/mus.20631","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,23]]}}}