{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T02:07:48Z","timestamp":1783044468736,"version":"3.54.6"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,10,20]],"date-time":"2006-10-20T00:00:00Z","timestamp":1161302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to determine whether there is any difference between voltage\u2010gated calcium\u2010channel antibody (VGCC\u2010Ab)\u2013positive and \u2013negative groups in Lambert\u2013Eaton myasthenic syndrome (LEMS), we compared the clinical and electrophysiological features between 13 patients with VGCC\u2010Ab and 6 VGCC\u2010Ab\u2013negative patients. No obvious difference was observed in the various clinical features or findings on single\u2010fiber electromyography between seropositive and seronegative cases. In seropositive cases, the compound muscle action potential (CMAP) amplitude was lower but the increment on post\u2010exercise facilitation (PEF) and high\u2010rate stimulation (HRS) was significantly higher than in the seronegative group, indicating that the repetitive nerve stimulation (RNS) test in the seropositive group is more typical of LEMS and more severe. A 100% increment as the diagnostic criterion in the routine RNS test was satisfied in all seropositive cases but in only three seronegative cases, whereas a 60% increment as the diagnostic criterion was found in all seronegative cases. The classic triad (low CMAP amplitude, decrement at low rate of stimulation, and increment at PEF or HRS) of RNS is rare, adding to the difficulty in diagnosing LEMS in the seronegative group, and making a 60% increment criterion more critical for the diagnosis of this disorder. Muscle Nerve, 2006<\/jats:p>","DOI":"10.1002\/mus.20672","type":"journal-article","created":{"date-parts":[[2006,10,20]],"date-time":"2006-10-20T20:46:28Z","timestamp":1161377188000},"page":"178-183","source":"Crossref","is-referenced-by-count":49,"title":["Electrophysiological differences in seropositive and seronegative Lambert\u2013Eaton myasthenic syndrome"],"prefix":"10.1002","volume":"35","author":[{"given":"Shin J.","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Hatanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwen C.","family":"Claussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Sher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,18]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"612","article-title":"Defect of neuromuscular conduction associated with malignant neoplasms","volume":"187","author":"Lambert EH","year":"1956","journal-title":"Am J Physiol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506013322203"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)05303-8"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000037485.56217.5F"},{"key":"e_1_2_6_6_2","volume-title":"Electromyography. 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