{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:05:39Z","timestamp":1767704739325},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,8]],"date-time":"2006-12-08T00:00:00Z","timestamp":1165536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The patterns of normal daily activity that are required to maintain normal skeletal muscle properties remain unknown. The present study was designed to determine whether spinal cord isolation can be used as a reliable experimental model of neuromuscular inactivity, that is, as a baseline for the absence of activity. Electromyograms (EMGs) were recorded from selected hindlimb muscles of unanesthetized rats over 24\u2010hour periods before and 7, 30, 60, and 90 days after surgical isolation of the lumbar spinal cord. Our data indicate that some rat slow muscle fibers pre\u2010surgery were activated for less than 3 hours per day. Spinal cord isolation (SI) reduced the mean daily integrated EMG (IEMG) and daily EMG duration in the primary slow extensor muscle (soleus) to &lt;1% of control, and in the primary fast extensor muscles [medial gastrocnemius (MG) and vastus lateralis (VL)] to &lt;2% of control. These parameters were decreased to &lt;8% and 3% of control, respectively, in a primary fast flexor muscle, the tibialis anterior (TA). From 30 to 90 days post\u2010SI, the mean amplitudes of the spontaneous EMG bursts were relatively normal in the soleus, increased \u223c2\u2010fold in the MG and VL, and increased \u223c4\u2010fold in the TA. Some evidence of the normal antagonistic flexor\u2013extensor relationship was apparent in the brief periods of recorded activity post\u2010SI. These results indicate that SI eliminates nearly all of the normal EMG activity in the hindlimb muscles in the presence of relatively normal muscle innervation and functional intraspinal neural circuitry. Muscle Nerve, 2006<\/jats:p>","DOI":"10.1002\/mus.20706","type":"journal-article","created":{"date-parts":[[2006,12,8]],"date-time":"2006-12-08T18:19:59Z","timestamp":1165601999000},"page":"312-321","source":"Crossref","is-referenced-by-count":25,"title":["Is spinal cord isolation a good model of muscle disuse?"],"prefix":"10.1002","volume":"35","author":[{"given":"R. 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