{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:51:34Z","timestamp":1791427894479,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with mitochondrial myopathies (MM) or myophosphorylase deficiency (McArdle's disease, McA) show impaired capacity for O<jats:sub>2<\/jats:sub> extraction, low maximal aerobic power, and reduced exercise tolerance. Non\u2010invasive tools are needed to quantify the metabolic impairment. Six patients with MM, 6 with McA, 25 with symptoms of metabolic myopathy but negative biopsy (patient\u2010controls, P\u2010CTRL) and 20 controls (CTRL) underwent an incremental cycloergometric test. Pulmonary O<jats:sub>2<\/jats:sub> uptake (V\u0307O<jats:sub>2<\/jats:sub>) and vastus lateralis oxygenation indices (by near\u2010infrared spectroscopy, NIRS) were determined. Concentration changes of deoxygenated hemoglobin and myoglobin (\u0394[deoxy(Hb + Mb)]) were considered an index of O<jats:sub>2<\/jats:sub> extraction. \u0394[deoxy(Hb + Mb)] peak (percent limb ischemia) was lower in MM (25.3 \u00b1 12.0%) and McA (18.7 \u00b1 7.3) than in P\u2010CTRL (62.4 \u00b1 3.9) and CTRL (71.3 \u00b1 3.9) subjects. V\u0307O<jats:sub>2<\/jats:sub> peak and \u0394[deoxy(Hb + Mb)] peak were linearly related (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.83). In these patients, NIRS is a tool to detect and quantify non\u2010invasively the metabolic impairment, which may be useful in the follow\u2010up of patients and in the assessment of therapies and interventions. Muscle Nerve, 2006<\/jats:p>","DOI":"10.1002\/mus.20708","type":"journal-article","created":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T22:49:13Z","timestamp":1165013353000},"page":"510-520","source":"Crossref","is-referenced-by-count":109,"title":["Impaired oxygen extraction in metabolic myopathies: Detection and quantification by near\u2010infrared spectroscopy"],"prefix":"10.1002","volume":"35","author":[{"given":"Bruno","family":"Grassi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Marzorati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Lanfranconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Ferri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Longaretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Stucchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Vago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Marconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Morandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.3.837"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360606"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(95)00060-H"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0838.2001.110404.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00956.2002"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(98)00113-3"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1139\/h04-031"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00695.2002"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360603"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170216"},{"key":"e_1_2_7_13_2","first-page":"271","volume-title":"Exercise and circulation in health and disease","author":"Haller RG","year":"2000"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20881"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/eph8702456"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2001.00842.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.61.2.391"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1969.tb07314.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10077"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1117\/12.263747"},{"key":"e_1_2_7_21_2","first-page":"116","article-title":"Influence of adipose tissue on muscle oxygenation measurements with NIRS instrument","volume":"3194","author":"Matsushita K","year":"1998","journal-title":"Proc Soc Photo\u2010Opt Instrum Eng"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199905)22:5<621::AID-MUS11>3.0.CO;2-D"},{"key":"e_1_2_7_23_2","first-page":"123","article-title":"Near\u2010infrared spectroscopy: what can it tell us about oxygen saturation in skeletal muscle?","volume":"28","author":"McCully KK","year":"2000","journal-title":"Exerc Sport Sci Rev"},{"key":"e_1_2_7_24_2","volume-title":"Human circulation. 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