{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:11:14Z","timestamp":1790086274599,"version":"4.0.1"},"reference-count":126,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T00:00:00Z","timestamp":1173916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sporadic inclusion\u2010body myositis (sIBM) is the most common acquired muscle disease in Caucasians over the age of 50 years. Pathologically it is marked by inflammatory, degenerative, and mitochondrial changes that interact in a yet\u2010unknown way to cause progressive muscle degeneration and weakness. The cause of the disease is unknown, but it is thought to involve a complex interplay between environmental factors, genetic susceptibility, and aging. The strongest evidence for genetic susceptibility comes from studies of the major histocompatibility complex (MHC), where different combinations of alleles have been associated with sIBM in different ethnic groups. The rare occurrence of familial cases of inclusion\u2010body myositis (fIBM) adds additional evidence for genetic susceptibility. Other candidate genes such as those encoding some of the proteins accumulating in muscle fibers have been investigated, with negative results. The increased understanding of related disorders, the hereditary inclusion\u2010body myopathies (hIBM), may also provide clues to the underlying pathogenesis of sIBM, but to date there is no indication that the genes responsible for these conditions are involved in sIBM. This review summarizes current understanding of the contribution of genetic susceptibility factors to the development of sIBM. Muscle Nerve, 2007<\/jats:p>","DOI":"10.1002\/mus.20766","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T18:38:21Z","timestamp":1173983901000},"page":"549-561","source":"Crossref","is-referenced-by-count":36,"title":["Genetics of inclusion\u2010body myositis"],"prefix":"10.1002","volume":"35","author":[{"given":"M.","family":"Needham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.L.","family":"Mastaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Garlepp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,15]]},"reference":[{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400407"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.2.598"},{"key":"e_1_2_15_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(84)90053-4"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410419"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199811)21:11<1523::AID-MUS22>3.0.CO;2-#"},{"key":"e_1_2_15_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000061617.71839.42"},{"key":"e_1_2_15_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.2.460"},{"key":"e_1_2_15_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340408"},{"key":"e_1_2_15_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199310000-00006"},{"key":"e_1_2_15_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199305060-00007"},{"key":"e_1_2_15_12_2","first-page":"177","article-title":"Twisted tubulofilaments of inclusion body myositis muscle resemble paired helical filaments of Alzheimer brain and contain hyperphosphorylated tau","volume":"144","author":"Askanas V","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_15_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400223"},{"key":"e_1_2_15_14_2","first-page":"487","article-title":"SOD1 gene and protein in vacuolated muscle fibers of s\u2010IBM, h\u2010IBM, and in cultured human muscle after bAPP gene transfer","volume":"46","author":"Askanas V","year":"1996","journal-title":"Neurology"},{"key":"e_1_2_15_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199707070-00012"},{"key":"e_1_2_15_16_2","first-page":"889","article-title":"Light and electron microscopic immunolocalization of presenilin 1 in abnormal muscle fibers of patients with sporadic inclusion\u2010body myositis and autosomal\u2010recessive inclusion\u2010body myopathy","volume":"152","author":"Askanas V","year":"1998","journal-title":"Am J Pathol"},{"key":"e_1_2_15_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.7.592"},{"key":"e_1_2_15_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/60.1.1"},{"key":"e_1_2_15_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/08830738030180030401"},{"key":"e_1_2_15_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20186"},{"key":"e_1_2_15_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000192128.13875.1e"},{"key":"e_1_2_15_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.9.1385"},{"key":"e_1_2_15_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000148588.15052.4C"},{"key":"e_1_2_15_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0884-y"},{"key":"e_1_2_15_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.7.1302"},{"key":"e_1_2_15_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.11.1561"},{"key":"e_1_2_15_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00334447"},{"key":"e_1_2_15_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2004.10.001"},{"key":"e_1_2_15_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/111.5.1025"},{"key":"e_1_2_15_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201750200"},{"key":"e_1_2_15_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.12.1509"},{"key":"e_1_2_15_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0261"},{"key":"e_1_2_15_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440215"},{"key":"e_1_2_15_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-9877(02)00339-0"},{"key":"e_1_2_15_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(92)90023-G"},{"key":"e_1_2_15_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200006)47:6<811::AID-ANA16>3.0.CO;2-9"},{"key":"e_1_2_15_37_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5630"},{"key":"e_1_2_15_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng718"},{"key":"e_1_2_15_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9100"},{"key":"e_1_2_15_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/416483a"},{"key":"e_1_2_15_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200109000-00006"},{"key":"e_1_2_15_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/63.5.484"},{"key":"e_1_2_15_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2005.tb00504.x"},{"key":"e_1_2_15_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051021"},{"key":"e_1_2_15_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-003-0794-y"},{"key":"e_1_2_15_46_2","first-page":"281","article-title":"Inclusion body myositis and neuromuscular diseases with rimmed vacuoles","volume":"148","author":"Figarella\u2010Branger D","year":"1992","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_15_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65682-9"},{"key":"e_1_2_15_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1994.tb06604.x"},{"key":"e_1_2_15_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380619"},{"key":"e_1_2_15_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.19.7606"},{"key":"e_1_2_15_51_2","doi-asserted-by":"publisher","DOI":"10.1159\/000078488"},{"key":"e_1_2_15_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2005.07.003"},{"key":"e_1_2_15_53_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.8.1170"},{"key":"e_1_2_15_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380504"},{"key":"e_1_2_15_55_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.45.26774"},{"key":"e_1_2_15_56_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.25.15002"},{"key":"e_1_2_15_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)11108-U"},{"key":"e_1_2_15_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-005-1043-3"},{"key":"e_1_2_15_59_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000180407.15369.92"},{"key":"e_1_2_15_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150070079"},{"key":"e_1_2_15_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7753(04)74479-6"},{"key":"e_1_2_15_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1489"},{"key":"e_1_2_15_63_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199805000-00003"},{"key":"e_1_2_15_64_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.3.438"},{"key":"e_1_2_15_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65681-7"},{"key":"e_1_2_15_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0895-486"},{"key":"e_1_2_15_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230111"},{"key":"e_1_2_15_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00939-5"},{"key":"e_1_2_15_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100380200004"},{"key":"e_1_2_15_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(96)88774-2"},{"key":"e_1_2_15_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(98)00159-4"},{"key":"e_1_2_15_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(97)00245-2"},{"key":"e_1_2_15_73_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050528"},{"key":"e_1_2_15_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(00)00144-9"},{"key":"e_1_2_15_75_2","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2001.3256"},{"key":"e_1_2_15_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(03)00140-8"},{"key":"e_1_2_15_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05208-8"},{"key":"e_1_2_15_78_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.2.368"},{"key":"e_1_2_15_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-003-0204-3"},{"key":"e_1_2_15_80_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.11.2119"},{"key":"e_1_2_15_81_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199111000-00002"},{"key":"e_1_2_15_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199612)19:12<1605::AID-MUS11>3.0.CO;2-Q"},{"key":"e_1_2_15_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00216142"},{"key":"e_1_2_15_84_2","doi-asserted-by":"publisher","DOI":"10.1086\/302375"},{"key":"e_1_2_15_85_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.250289597"},{"key":"e_1_2_15_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2006.06.009"},{"key":"e_1_2_15_87_2","first-page":"1142","article-title":"Constitutive and cytokine\u2010induced expression of human leukocyte antigens and cell adhesion molecules by human myotubes","volume":"143","author":"Michaelis D","year":"1993","journal-title":"Am J Pathol"},{"key":"e_1_2_15_88_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400608"},{"key":"e_1_2_15_89_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.1.159"},{"key":"e_1_2_15_90_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2003.01251.x"},{"key":"e_1_2_15_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00134-7"},{"key":"e_1_2_15_92_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.16.9209"},{"key":"e_1_2_15_93_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21103"},{"key":"e_1_2_15_94_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.4.897"},{"key":"e_1_2_15_95_2","first-page":"80","article-title":"Molecular pathomechanism of distal myopathy with rimmed vacuoles","volume":"24","author":"Nishino I","year":"2005","journal-title":"Acta Myol"},{"key":"e_1_2_15_96_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000189818.63141.8c"},{"key":"e_1_2_15_97_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199507000-00012"},{"key":"e_1_2_15_98_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000192127.63013.8d"},{"key":"e_1_2_15_99_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.8.1235"},{"key":"e_1_2_15_100_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi0522504"},{"key":"e_1_2_15_101_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200006)23:6<970::AID-MUS20>3.0.CO;2-I"},{"key":"e_1_2_15_102_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.1178"},{"key":"e_1_2_15_103_2","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.5858\/2001-125-1326-BBXABE","article-title":"Bcl\u20102, Bcl\u2010x and Bax expression by immunohistochemistry in inclusion body myositis: a study of 27 cases","volume":"125","author":"Prayson RA","year":"2001","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_15_104_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1999.tb01398.x"},{"key":"e_1_2_15_105_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2004.00310.x"},{"key":"e_1_2_15_106_2","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2001.0972"},{"key":"e_1_2_15_107_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh518"},{"key":"e_1_2_15_108_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20680"},{"key":"e_1_2_15_109_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.025494"},{"key":"e_1_2_15_110_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199306000-00055"},{"key":"e_1_2_15_111_2","first-page":"1280","article-title":"Abnormal accumulation of prion protein mRNA in muscle fibers of patients with sporadic inclusion\u2010body myositis and hereditary inclusion\u2010body myopathy","volume":"145","author":"Sarkozi E","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_15_112_2","first-page":"A331","article-title":"Distinct interplay between inflammatory and degeneration\u2010associated molecules in sporadic IBM","volume":"64","author":"Schmidt J","year":"2005","journal-title":"Neurology"},{"key":"e_1_2_15_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2006.02.002"},{"key":"e_1_2_15_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90425-7"},{"key":"e_1_2_15_115_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10358"},{"key":"e_1_2_15_116_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380222"},{"key":"e_1_2_15_117_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.4.977"},{"key":"e_1_2_15_118_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.4.653"},{"key":"e_1_2_15_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(93)90113-F"},{"key":"e_1_2_15_120_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.42.1035"},{"key":"e_1_2_15_121_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010100428"},{"key":"e_1_2_15_122_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000039780.13681.AD"},{"key":"e_1_2_15_123_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000192107.17175.39"},{"key":"e_1_2_15_124_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1332"},{"key":"e_1_2_15_125_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000061520.63546.8F"},{"key":"e_1_2_15_126_2","doi-asserted-by":"publisher","DOI":"10.1038\/382685a0"},{"key":"e_1_2_15_127_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2001.tb00390.x"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.20766","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.20766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T13:54:02Z","timestamp":1696859642000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.20766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,15]]},"references-count":126,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1002\/mus.20766"],"URL":"https:\/\/doi.org\/10.1002\/mus.20766","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,15]]}}}