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We verified that cromolyn, a mast\u2010cell stabilizer agent, stabilized dystrophic muscle fibers using Evans blue dye as a marker of sarcolemma leakiness. <jats:italic>Mdx<\/jats:italic> mice (<jats:italic>n<\/jats:italic> = 8; 14 days of age) received daily intraperitoneal injections of cromolyn (50 mg\/kg body weight) for 15 days. Untreated <jats:italic>mdx<\/jats:italic> mice (<jats:italic>n<\/jats:italic> = 8) were injected with saline. Cryostat cross\u2010sections of the sternomastoid, tibialis anterior, and diaphragm muscles were stained with hematoxylin and eosin. Cromolyn dramatically reduced Evans blue dye\u2013positive fibers in all muscles (<jats:italic>P<\/jats:italic> &lt; 0.05; Student's <jats:italic>t<\/jats:italic>\u2010test) and led to a significant increase in the percentage of fibers with peripheral nuclei. This study supports the protective effects of cromolyn in dystrophic muscles and further indicates its action against muscle fiber leakiness in muscles that are differently affected by the lack of dystrophin. 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