{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:12:10Z","timestamp":1787040730579,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T00:00:00Z","timestamp":1203465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An incremental response after brief exercise or high\u2010rate stimulation on the repetitive nerve stimulation (RNS) test is a critical diagnostic criterion for Lambert\u2013Eaton myasthenic syndrome (LEMS). This prospective study was performed to determine what duration of exercise shows the highest diagnostic sensitivity for LEMS. The compound muscle action potential amplitude in the abductor digiti quinti muscle was obtained at rest and after 5 s, 10 s, 15 s, 20 s, 25 s, and 30 s of exercise. Incremental responses were compared for the different exercise durations in 24 studies performed in nine LEMS patients. The increment was highest with 5\u2010s and 10\u2010s exercises (244%\u2013243%) and lowest with 30\u2010s exercise (84%). A gradual decrease in the increment was noted from 5\u2010 to 30\u2010s exercise. A significant difference in the increment was noted between 5\u2010 to 10\u2010s and 20\u2010s to 30\u2010s exercise. There was significantly higher diagnostic sensitivity with the 10\u2010s exercise compared with 30\u2010s exercise at 100% increment and 60% increment levels. Higher increment and diagnostic sensitivity were achieved with 10\u2010s exercise than with 30\u2010s exercise. Thus, 10\u2010s exercise should be the standard protocol for the RNS test for LEMS. Muscle Nerve, 2008<\/jats:p>","DOI":"10.1002\/mus.20979","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T22:27:15Z","timestamp":1203546435000},"page":"572-575","source":"Crossref","is-referenced-by-count":52,"title":["Ten\u2010second exercise is superior to 30\u2010second exercise for post\u2010exercise facilitation in diagnosing Lambert\u2013Eaton myasthenic syndrome"],"prefix":"10.1002","volume":"37","author":[{"given":"Yuki","family":"Hatanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin J.","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0987-7053(05)80005-X"},{"key":"e_1_2_6_3_2","first-page":"362","volume-title":"Myasthenia gravis","author":"Lambert EH","year":"1961"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/111.3.577"},{"key":"e_1_2_6_5_2","volume-title":"Electromyography. 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