{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:47:43Z","timestamp":1696927663391},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,5,27]],"date-time":"2008-05-27T00:00:00Z","timestamp":1211846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lambert\u2013Eaton syndrome (LES) is an immune\u2010mediated disorder of the presynaptic neuromuscular junction due to the blocking effect of the voltage\u2010gated calcium channel (VGCC) antibodies. Small\u2010cell lung cancer (SCLC) is the most common cause of LES. We report an unusual case of LES associated with large\u2010cell neuroendocrine carcinoma (LCNEC) of the lung. In this case, clinical symptoms of LES predated the diagnosis of LCNEC by 6 years. After tumor resection, the patient experienced clinical and electrophysiological improvement. In addition, he had a decrease in VGCC antibody titer from 130 to 80 pmol\/L. The onset of LES can be prolonged, and tumor surveillance should continue in these cases. Muscle Nerve 37: 786\u2013789, 2008<\/jats:p>","DOI":"10.1002\/mus.21032","type":"journal-article","created":{"date-parts":[[2008,5,27]],"date-time":"2008-05-27T16:58:02Z","timestamp":1211907482000},"page":"786-789","source":"Crossref","is-referenced-by-count":9,"title":["Lambert\u2013Eaton syndrome with large\u2010cell neuroendocrine carcinoma of the lung"],"prefix":"10.1002","volume":"37","author":[{"given":"Christian","family":"Grommes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Preston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaid","family":"Al\u2010Kadhimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amer","family":"Alshekhlee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,5,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.02.064"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1490"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.10.1552"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2004.05.052"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199411000-00030"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90179-9"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880120802"},{"key":"e_1_2_5_9_2","first-page":"612","article-title":"Defect of neuromuscular conduction associated with malignant neoplasm","volume":"187","author":"Lambert E","year":"1956","journal-title":"Am J Physiol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)76153-5"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.01.028"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/111.3.577"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2003.09.070"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(02)00080-6"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb11024.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000130254.27019.14"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20332"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.21032","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.21032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T23:40:10Z","timestamp":1696894810000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.21032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,27]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1002\/mus.21032"],"URL":"https:\/\/doi.org\/10.1002\/mus.21032","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,27]]}}}